Automated Assessment of Cerebral Arterial Perforator Function on 7T MRI.
Automated Assessment of Cerebral Arterial Perforator Function on 7T MRI.
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DOI：
10.1002/jmri.27304
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Zwanenburg JJM
中科院分区：
文献类型：
--
作者：
Arts T;Siero JCW;Biessels GJ;Zwanenburg JJM
Blood flow velocity and pulsatility of small cerebral perforating arteries can be measured using 7T quantitative 2D phase contrast (PC) MRI. However, ghosting artifacts arising from subject movement and pulsating large arteries cause false positives when applying a previously published perforator detection method. To develop a robust, automated method to exclude perforators located in ghosting artifacts. Retrospective. Fifteen patients with vascular cognitive impairment or carotid occlusive disease and 10 healthy controls. 7T/cardiac‐gated 2D PC MRI. Perforators were automatically excluded from ghosting regions, which were defined as bands in the phase‐encoding direction of large arteries. As reference, perforators were manually excluded by two raters (T.A., J.J.M.Z.), based on perforator location with respect to visible ghosting artifacts. The performance of both censoring methods was assessed for the number of (Nincluded), mean velocity (Vmean), and pulsatility index (PI) of the included perforators. For within‐method comparisons, inter‐ and intrarater reliability were assessed for the manual method, and test–retest reliability was assessed for both methods from repeated 2D PC scans (without repositioning). Intraclass correlation coefficients (ICCs) and their 95% confidence intervals (CIs) were determined for Nincluded, Vmean, and PI for all within‐method comparisons. The ICC to compare between the two methods was determined with the use of both (test–retest) scans using a multilevel nonlinear mixed model. The automated censoring method showed a moderate to good ICC (95% CI) vs. manual censoring for Nincluded (0.73 [0.58–0.87]) and Vmean (0.90 [0.84–0.96]), and a moderate ICC for PI (0.57 [0.37–0.76]). The test–retest reliability of the manual censoring method was considerably lower than the interrater and intrarater reliability, indicating that scanner noise dominates the uncertainty of the analysis. The proposed automated censoring method can reliably exclude small perforators affected by ghosting artifacts. 3. 1.
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影响因子：
3.3
作者：
Geurts, Lennart;Biessels, Geert Jan;Zwanenburg, Jaco
通讯作者：
Zwanenburg, Jaco
DOI：
10.1073/pnas.1317424111
发表时间：
2014-04-22
影响因子：
11.1
作者：
Zeng, Ling-Li;Wang, Danhong;Liu, Hesheng
通讯作者：
Liu, Hesheng
影响因子：
2.9
作者：
Bouvy, W. H.;Geurts, L. J.;Zwanenburg, J. J. M.
通讯作者：
Zwanenburg, J. J. M.
较高的主动脉僵硬与老年人的脑血流量较低和脑血管反应性有关。
影响因子：
37.8
作者：
Jefferson AL;Cambronero FE;Liu D;Moore EE;Neal JE;Terry JG;Nair S;Pechman KR;Rane S;Davis LT;Gifford KA;Hohman TJ;Bell SP;Wang TJ;Beckman JA;Carr JJ
通讯作者：
Carr JJ
影响因子：
8.3
作者：
Geurts, Lennart J.;Zwanenburg, Jaco J. M.;Biessels, Geert Jan
通讯作者：
Biessels, Geert Jan