BAL Fluid 8-Isoprostane Concentrations in Eosinophilic Bronchitis and Asthma
BAL Fluid 8-Isoprostane Concentrations in Eosinophilic Bronchitis and Asthma
复制标题
嗜酸性支气管炎和哮喘中 BAL 液 8-异前列烷浓度
DOI：
10.1080/02770900903067879
复制
发表时间：
2009
影响因子：
1.9
通讯作者：
K. Lai
中科院分区：
文献类型：
--
作者：
Jia;Qingling Zhang;N. Zhong;K. Lai
背景。氧化应激在哮喘的病理生理中起着重要作用。但未对非哮喘性嗜酸性支气管炎（EB）患者气道氧化应激进行评估。8-外前列腺素F2alpha（8-异前列腺素）是氧化应激的生物标志物。目标。我们试图确定氧化应激（通过8-异前列腺素测量）是否发生在EB中，以及8-异前列腺素是否与EB和哮喘的气道功能有关。方法。我们测量了11名EB患者、10名哮喘患者和9名健康对照者的支气管肺泡灌洗液中8-异前列腺素的浓度。酶免疫法测定8-异前列腺素。结果。我们发现EB和哮喘患者BAL液中8-异前列腺素浓度均升高。哮喘患者BAL液中8-异前列腺素的中位浓度（12.78 pg/mL）明显高于EB （8.34 pg/mL）和健康对照组（5.07 pg/mL）。结论。我们的研究表明，哮喘组的氧化应激明显增加，EB组的氧化应激程度比哮喘组轻，这可以从BAL液中8-异前列腺素的浓度反映出来。EB和哮喘患者气道功能的差异可能与气道中8-异前列腺素浓度的不同升高有关。
Background. Oxidative stress has an important role in the pathophysiology of asthma. But oxidative stress of airway has not been assessed in patients with nonasthmatic eosinophilic bronchitis (EB). 8-epi-prostaglandin F2alpha (8-isoprostane) is a biomarker of oxidative stress. Objectives. We sought to determine whether oxidative stress (measured by 8-isoprostane) occurs in EB and whether 8-isoprostane is associated with airway function in EB and asthma. Methods. We measured 8-isoprostane concentrations in the bronchoalveolar lavage (BAL) fluid from 11 subjects with EB, 10 subjects with asthma, and 9 healthy control subjects. 8-isoprostane was measured by enzyme immunoassays. Results. We found that BAL fluid 8-isoprostane concentrations were raised both in EB and asthma. The median concentrations of 8-isoprostane in BAL fluid were significantly higher in subjects with asthma (12.78 pg/mL) when compared with EB (8.34 pg/mL) and healthy control subjects (5.07 pg/mL). Conclusions. Our study shows that oxidative stress is increased significantly in asthmatic subjects and the degree of oxidative stress in EB subjects is milder than that in asthma, as reflected by 8-isoprostane concentrations in the BAL fluid. The difference in airway function observed in subjects with EB and asthma could be associated with different elevation in 8-isoprostane concentration in the airways.
登录
查看更多内容
DOI：
10.1164/ajrccm.162.3.9909064
发表时间：
2000-09-01
影响因子：
24.7
作者：
Brichtling, CE;Ward, R;Pavord, ID
通讯作者：
Pavord, ID
影响因子：
7.4
作者：
Roberts, LJ;Morrow, JD
通讯作者：
Morrow, JD
哮喘患者的低密度嗜酸性粒细胞产生超氧化物。
DOI：
10.1164/ajrccm/142.1.120
发表时间：
1990
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Sedgwick,JB;Geiger,KM;Busse,WW
通讯作者：
Busse,WW
影响因子：
7.4
作者：
Meghavi Talati;B. Meyrick;R. Peebles;S. Davies;R. Dworski;R. Mernaugh;D. Mitchell;M. Boothby;L. Roberts;J. Sheller
通讯作者：
Meghavi Talati;B. Meyrick;R. Peebles;S. Davies;R. Dworski;R. Mernaugh;D. Mitchell;M. Boothby;L. Roberts;J. Sheller