Immune Responses to IAV Infection and the Roles of L-Selectin and ADAM17 in Lymphocyte Homing.
Immune Responses to IAV Infection and the Roles of L-Selectin and ADAM17 in Lymphocyte Homing.
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DOI：
10.3390/pathogens11020150
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发表时间：
2022-01-25
期刊：
影响因子：
--
通讯作者：
Ager A
中科院分区：
文献类型：
--
作者：
Reed SG;Ager A
甲型流感病毒（IAV）感染是一种全球公共卫生负担，每年导致多达650，000人死亡。目前，每年的疫苗接种计划和抗病毒药物的益处有限;因此，对IAV的研究至关重要。白细胞运输是协调对感染的免疫应答以保护宿主的关键过程。它涉及血管和白细胞上的几种归巢分子和受体。这一过程的关键介质是跨膜糖蛋白L-选择素，其结合血管内皮细胞上的血管地址素。L-选择素经典地介导幼稚和中枢记忆淋巴细胞通过高内皮微静脉（HEVs）归巢至淋巴结。最近的研究发现，L-选择素对于活化的CD 8 + T细胞归巢到流感感染的肺和减少病毒载量是必不可少的。解整合素和金属蛋白酶17（ADAM 17）是L-选择素的细胞表面水平的主要调节剂。了解调节这两种蛋白质的机制对于理解T细胞向IAV感染部位的募集至关重要。本文综述了人和小鼠对IAV感染的免疫应答，并讨论了L-selectin和ADAM 17在IAV感染过程中T淋巴细胞归巢中的作用。
Influenza A virus (IAV) infection is a global public health burden causing up to 650,000 deaths per year. Yearly vaccination programmes and anti-viral drugs currently have limited benefits; therefore, research into IAV is fundamental. Leukocyte trafficking is a crucial process which orchestrates the immune response to infection to protect the host. It involves several homing molecules and receptors on both blood vessels and leukocytes. A key mediator of this process is the transmembrane glycoprotein L-selectin, which binds to vascular addressins on blood vessel endothelial cells. L-selectin classically mediates homing of naïve and central memory lymphocytes to lymph nodes via high endothelial venules (HEVs). Recent studies have found that L-selectin is essential for homing of activated CD8+ T cells to influenza-infected lungs and reduction in virus load. A disintegrin and metalloproteinase 17 (ADAM17) is the primary regulator of cell surface levels of L-selectin. Understanding the mechanisms that regulate these two proteins are central to comprehending recruitment of T cells to sites of IAV infection. This review summarises the immune response to IAV infection in humans and mice and discusses the roles of L-selectin and ADAM17 in T lymphocyte homing during IAV infection.
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影响因子：
20.3
作者：
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通讯作者：
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影响因子：
64.5
作者：
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发表时间：
2010
期刊：
Viruses
影响因子：
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作者：
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通讯作者：
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发表时间：
2001-05-07
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影响因子：
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通讯作者：
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DOI：
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发表时间：
2016-02-23
影响因子：
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作者：
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通讯作者：
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