Measures of blood pressure and cognition in dialysis patients.
Measures of blood pressure and cognition in dialysis patients.
复制标题
透析患者的血压和认知度量。
DOI：
10.1111/j.1542-4758.2012.00718.x
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Sarnak MJ
中科院分区：
文献类型：
--
作者：
Giang LM;Tighiouart H;Lou KV;Agganis B;Drew DA;Shaffi K;Scott T;Weiner DE;Sarnak MJ
关于维持性透析患者血压与认知功能关系的报道较少。认知和透析研究是一项针对波士顿地区 6 个血液透析中心的认知功能及其危险因素的持续调查。在这项分析中，我们使用针对年龄、性别、种族、教育程度和终末期肾病 (ESRD) 主要原因进行调整的单变量和多变量线性回归模型，评估了不同认知功能领域与收缩压和舒张压、脉压和收缩压透析中变化之间的关系。 314 名参与者中，平均年龄为 63 岁； 47% 是女性，22% 是非裔美国人，48% 患有糖尿病。收缩压、舒张压、脉压和透析内收缩压变化的平均值（SD）分别为141（21）、73（12）、68（15）和-10（24）毫米汞柱。在单变量分析中，舒张压较低和脉压较高的参与者在主要评估执行功能和处理速度的认知测试中表现较差。然而，在多变量分析中，这些关系并不具有统计显着性。在单变量或多变量分析中，认知功能与收缩压或透析中收缩压变化之间没有关联。在横断面分析中，我们发现不同的血压测量值与认知功能之间没有关联。需要纵向研究来证实这些结果。
There are few reports on the relationship of blood pressure with cognitive function in maintenance dialysis patients. The Cognition and Dialysis Study is an ongoing investigation of cognitive function and its risk factors in 6 Boston area hemodialysis units. In this analysis we evaluated the relationship between different domains of cognitive function with systolic and diastolic blood pressure, pulse pressure, and intradialytic changes in systolic blood pressure, using univariate and multivariable linear regression models adjusted for age, sex, race, education and primary cause of end stage renal disease (ESRD). Among 314 participants, mean age was 63 years; 47% were female, 22% African American and 48% had diabetes. Mean (SD) of systolic blood pressure, diastolic blood pressure, pulse pressure and intradialytic change in systolic blood pressure were 141 (21), 73 (12), 68 (15) and -10 (24) mm Hg, respectively. In univariate analyses, the performance on cognitive tests primarily assessing executive function and processing speeds was worse among participants with lower diastolic blood pressure and higher pulse pressure. These relationships were not statistically significant, however, in multivariable analyses. There was no association between cognitive function and systolic blood pressure or intradialytic change in systolic blood pressure in either univariate or multivariable analyses. We found no association between different measures of blood pressure and cognitive function in cross sectional analysis. Longitudinal studies are needed to confirm these results.
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