The Role of Comorbidities in Difficult-to-Control Asthma in Adults and Children.
The Role of Comorbidities in Difficult-to-Control Asthma in Adults and Children.
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DOI：
10.1016/j.jaip.2021.11.016
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Fuhlbrigge AL
中科院分区：
文献类型：
--
作者：
Gaffin JM;Castro M;Bacharier LB;Fuhlbrigge AL
评估哮喘合并症，即对哮喘病理生物学产生不利影响或损害其对治疗反应的疾病，是评估和管理难治性哮喘患者的基本步骤。识别并有效治疗哮喘合并症，如肥胖、阻塞性睡眠呼吸暂停和慢性鼻窦炎伴鼻息肉，可改善哮喘控制并减少加重。此外，识别共病T2炎性疾病可能有助于指导生物治疗的最佳选择。在这里，我们描述了成人和儿童难以控制的哮喘中常见的合并症，讨论了与哮喘发病率和治疗获益相关的证据，并提供了如何以及何时评估合并症的信息。
Assessment of asthma comorbidities, conditions that adversely affect the pathobiology of asthma or impair its response to therapies, is a fundamental step in the evaluation and management of patients with difficult-to-treat asthma. Identifying and effectively treating asthma comorbidities, such as obesity, obstructive sleep apnea, and chronic sinusitis with nasal polyps may improve asthma control and reduce exacerbations. Additionally, identifying comorbid T2 inflammatory conditions may help guide optimal selection of biologic therapies. Here, we describe common comorbid conditions found in adult and pediatric difficult-to-control asthma, discuss evidence for the association with asthma morbidity and treatment benefit, and provide information on how and when to assess comorbidities.
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影响因子：
6.1
作者：
Agarwal, R.;Chakrabarti, A.;Denning, D. W.
通讯作者：
Denning, D. W.
影响因子：
2.6
作者：
Shan LS;Zhou QL;Shang YX
通讯作者：
Shang YX
影响因子：
5.6
作者：
Bodkhe, Shradha;Nikam, Mayuri;Patel, Kavit
通讯作者：
Patel, Kavit
影响因子：
15.8
作者：
Bhattacharjee, Rakesh;Choi, Beatrix H.;Mokhlesi, Babak
通讯作者：
Mokhlesi, Babak
影响因子：
7.2
作者：
Belanger K;Hellenbrand ME;Holford TR;Bracken M
通讯作者：
Bracken M