Bidirectional Association Between Asthma and Obesity During Childhood and Adolescence: A Systematic Review and Meta-Analysis.
Bidirectional Association Between Asthma and Obesity During Childhood and Adolescence: A Systematic Review and Meta-Analysis.
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DOI：
10.3389/fped.2020.576858
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发表时间：
2020
影响因子：
2.6
通讯作者：
Shang YX
中科院分区：
文献类型：
--
作者：
Shan LS;Zhou QL;Shang YX
目的：小儿哮喘和肥胖同时发生已被广泛报道，但这两种疾病之间的因果关系仍不清楚。这项荟萃分析的目的是探讨儿童和青少年的这两种疾病是否存在双向关联的可能性。方法：检索截至 2020 年 8 月的 PubMed、Embase、Web of Science 和 CENTRAL 数据库。报告肥胖与医生诊断哮喘风险或医生诊断哮喘与儿童和青少年肥胖风险之间关系的队列研究符合审查资格。结果：四个数据库共识别出 3,091 条记录，最终纳入 9 条。六项研究报告了肥胖与哮喘风险之间的关联；三项研究报告了哮喘与儿童肥胖风险之间的关联。根据纽卡斯尔-渥太华质量评估量表的评估，所有研究均被评为高质量研究。在儿童和青少年中，肥胖与医生诊断的哮喘风险增加之间存在统计学上显着的关联。汇总 RR 为 1.39（95% CI：1.28，1.50；p < 0.001），各研究之间存在显着异质性（I2 = 81.7%；异质性 < 0.001）。男孩的汇总 RR 为 1.53（95% CI：1.17, 1.99；p = 0.002），但在女孩中未观察到如此显着的相关性（RR = 1.17，95% CI：0.79, 1.72；p = 0.434）。对于哮喘与儿童肥胖风险的关联，汇总 RR 为 1.47（95%CI：1.25，1.72；p < 0.001），无统计异质性（I2 = 0%，异质性 = 0.652）。结论：儿童期和青春期肥胖与哮喘之间存在双向关联，表明儿童期肥胖导致哮喘发病率增加；同时，儿童哮喘还可能增加儿童和青少年肥胖的风险。
Objective: Co-occurrence of pediatric asthma and obesity has been widely reported, yet the causal directions between these two disorders are still not well-understood. The objective of this meta-analysis is to explore whether there is a possibility of a bidirectional association for these two disorders in children and adolescents. Methods: PubMed, Embase, Web of Science, and CENTRAL databases were searched up to August 2020. Cohort studies reporting the associations of obesity with risk of physician-diagnosed asthma or physician-diagnosed asthma with risk of obesity in children and adolescents were eligible for the review. Results: A total of 3,091 records were identified from the four databases, with final inclusion of nine. Six studies reported the association between obesity and risk of asthma; three studies reported the association between asthma and risk of childhood obesity. As evaluated by the Newcastle–Ottawa quality assessment scale, all studies were assessed as high-quality studies. There was a statistically significant association between obesity and increased risk of physician-diagnosed asthma in children and adolescents. The pooled RR was 1.39 (95% CI: 1.28, 1.50; p < 0.001), with significant heterogeneity across studies (I2 = 81.7%; pheterogeneity < 0.001). The pooled RR in boys was 1.53 (95% CI: 1.17, 1.99; p = 0.002), but such a significant association was not observed in girls (RR = 1.17, 95% CI: 0.79, 1.72; p = 0.434). For the association of asthma with risk of childhood obesity, the pooled RR was 1.47 (95%CI: 1.25, 1.72; p < 0.001) without statistical heterogeneity (I2 = 0%, pheterogeneity = 0.652). Conclusion: There is a bidirectional association between obesity and asthma during childhood and adolescence, suggesting that childhood obesity drives an increase in the onset of asthma; meanwhile, childhood asthma may also increase risk of obesity for children and adolescents.
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影响因子：
2.4
作者：
Egan KB;Ettinger AS;Bracken MB
通讯作者：
Bracken MB
DOI：
10.1136/archdischild-2015-308340
发表时间：
2016-05-01
影响因子：
4.4
作者：
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通讯作者：
McCormick, Marie C.
影响因子：
2.2
作者：
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通讯作者：
Kacker, Raghu
影响因子：
8
作者：
Barlow, Sarah E.
通讯作者：
Barlow, Sarah E.
影响因子：
17.1
作者：
Bokulich NA;Chung J;Battaglia T;Henderson N;Jay M;Li H;D Lieber A;Wu F;Perez-Perez GI;Chen Y;Schweizer W;Zheng X;Contreras M;Dominguez-Bello MG;Blaser MJ
通讯作者：
Blaser MJ