COVID-19: persistence of symptoms and lung alterations after 3-6 months from hospital discharge.
COVID-19: persistence of symptoms and lung alterations after 3-6 months from hospital discharge.
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COVID-19：出院3-6个月后，症状和肺部改变的持久性。
DOI：
10.1007/s15010-021-01638-1
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发表时间：
2021-10
期刊：
影响因子：
7.5
通讯作者：
Faraone A
中科院分区：
文献类型：
--
作者：
Fortini A;Torrigiani A;Sbaragli S;Lo Forte A;Crociani A;Cecchini P;Innocenti Bruni G;Faraone A
目前几乎没有关于新冠肺炎患者持续症状和晚期器官损害的数据。这项前瞻性研究旨在评估非强化新冠肺炎病房出院患者的随访计划的结果。出院后3~6个月，纳入新冠肺炎患者59例(男性31例，年龄68.2 ± 12.8岁)。46名患者因无法追踪、拒绝或无法提供知情同意而被排除在外。随访包括既往史(包括结构化问卷)、体格检查、血液检查、心电图、下肢静脉超声(US)、胸部超声和肺功能测定(肺一氧化碳弥散量(DLCO)。22%的患者无残留症状，28.8%的患者有1或2个症状，49.2%的患者有3个或以上的症状。最常见的症状是疲劳、劳力性呼吸困难、失眠和焦虑。在炎症和凝血指标中，只有纤维蛋白原的中位数略高于正常。深静脉血栓形成1例(1.7%)。胸部超声发现15例(25.4%)患者有轻微的肺部改变，其中10例报告有劳力性呼吸困难。19例(37.2%)DLCO轻度或中度降低，其中13例主诉为劳力性呼吸困难。这些结果突显了相当大比例的新冠肺炎患者(77.8%)在出院后3-6个月继续抱怨症状。劳力性呼吸困难与肺部超声异常的持续和弥散功能改变显著相关。需要长期随访以评估新冠肺炎急性后遗症的长期演变。
Few data are currently available on persistent symptoms and late organ damage in patients who have suffered from COVID-19. This prospective study aimed to evaluate the results of a follow-up program for patients discharged from a nonintensive COVID-19 ward. 3–6 months after hospital discharge, 59 of 105 COVID-19 patients (31 males, aged 68.2 ± 12.8 years) were recruited in the study. Forty-six patients were excluded because of nontraceability, refusal, or inability to provide informed consent. The follow-up consisted of anamnesis (including a structured questionnaire), physical examination, blood tests, ECG, lower limb compression venous ultrasound (US), thoracic US, and spirometry with diffusion lung capacity for carbon monoxide (DLCO). 22% of patients reported no residual symptoms, 28.8% 1 or 2 symptoms and 49.2% 3 or more symptoms. The most frequently symptoms were fatigue, exertional dyspnea, insomnia, and anxiety. Among the inflammatory and coagulation parameters, only the median value of fibrinogen was slightly above normal. A deep vein thrombosis was detected in 1 patient (1.7%). Thoracic US detected mild pulmonary changes in 15 patients (25.4%), 10 of which reported exertional dyspnea. DLCO was mildly or moderately reduced in 19 patients (37.2%), 13 of which complained of exertional dyspnea. These results highlight that a substantial percentage of COVID-19 patients (77.8%) continue to complain of symptoms 3–6 months after hospital discharge. Exertional dyspnea was significantly associated with the persistence of lung US abnormalities and diffusing capacity alterations. Extended follow-up is required to assess the long-term evolution of postacute sequelae of COVID-19.
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影响因子：
4.2
作者：
Spinicci M;Vellere I;Graziani L;Tilli M;Borchi B;Mencarini J;Campolmi I;Gori L;Rasero L;Fattirolli F;Olivotto I;Lavorini F;Marchionni N;Zammarchi L;Bartoloni A;Careggi Post-acute COVID-19 Study Group
通讯作者：
Careggi Post-acute COVID-19 Study Group
影响因子：
10
作者：
Hui, DS;Joynt, GM;Sung, JJY
通讯作者：
Sung, JJY
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
28.2
作者：
Chen, Jun;Qi, Tangkai;Lu, Hongzhou
通讯作者：
Lu, Hongzhou
影响因子：
4.6
作者：
Bosso G;Allegorico E;Pagano A;Porta G;Serra C;Minerva V;Mercurio V;Russo T;Altruda C;Arbo P;De Sio C;Dello Vicario F;Numis FG
通讯作者：
Numis FG