The molecular mechanisms of Foxp3 gene regulation.
The molecular mechanisms of Foxp3 gene regulation.
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DOI：
10.1016/j.smim.2011.06.005
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发表时间：
2011-12
影响因子：
7.8
通讯作者：
Chen W
中科院分区：
文献类型：
--
作者：
Maruyama T;Konkel JE;Zamarron BF;Chen W
可以理解的是，诱导Foxp3基因表达和获得调节性T细胞命运是一个高度受控的过程，也是许多研究者想要阐明的一个过程。在对Foxp3基因表达调控的研究中，已经发现了几个保守的非编码区，并探索了各种转录因子在这些位点的作用。由此可见，许多因素，有些是积极的，有些是消极的，相互作用共同驱动Foxp3基因的表达，然后在Foxp3+调节性T细胞中维持其表达。TCR信号是Foxp3基因表达的必要条件，TGF-β是naïve T细胞启动Foxp3基因表达的关键细胞因子。但已知其他信号通路也在适当协调Foxp3基因表达和调节性T细胞扩增中发挥作用。在这里，我们回顾了最近在理解驱动Foxp3基因表达和允许功能调节性T细胞发育的复杂分子事件方面的进展。
Induction of Foxp3 gene expression and acquisition of regulatory T cell fate is, understandably, a highly controlled process and one which many investigators want to illuminate. In studying the regulation of Foxp3 gene expression, several conserved non-coding regions have been identified and the role of various transcription factors at these sites has been explored. What emerges, is that many factors, some positive, some negative, interact to collectively drive Foxp3 gene expression and then maintain its expression in Foxp3+ regulatory T cells. TCR signaling is imperative for Foxp3 gene expression and TGF-β is a key cytokine for initiating Foxp3 gene expression in naïve T cells. But other signaling pathways are also known to play a role in properly orchestrating Foxp3 gene expression and regulatory T cell expansion. Here we review the recent progress in understanding the complex molecular events that drive Foxp3 gene expression and allow functional regulatory T cells to develop.
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影响因子：
32.4
作者：
Fontenot, JD;Rasmussen, JP;Rudensky, AY
通讯作者：
Rudensky, AY
影响因子：
64.8
作者：
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作者：
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DOI：
10.1073/pnas.0605333103
发表时间：
2006-08-22
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
100.3
作者：
Huehn, Jochen;Polansky, Julia K.;Hamann, Alf
通讯作者：
Hamann, Alf