Single nucleotide polymorphisms in the PRDX3 and RPS19 and risk of HPV persistence and cervical precancer/cancer.
Single nucleotide polymorphisms in the PRDX3 and RPS19 and risk of HPV persistence and cervical precancer/cancer.
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PRDX3 和 RPS19 中的单核苷酸多态性与 HPV 持续存在和宫颈癌前/癌症的风险
DOI：
10.1371/journal.pone.0033619
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Wang SS
中科院分区：
文献类型：
--
作者：
Safaeian M;Hildesheim A;Gonzalez P;Yu K;Porras C;Li Q;Rodriguez AC;Sherman ME;Schiffman M;Wacholder S;Burk R;Herrero R;Burdette L;Chanock SJ;Wang SS
背景：宿主遗传因素可能影响从致癌性人乳头瘤病毒（HPV）感染（宫颈癌的病原体）到持续性HPV感染，进而发展为宫颈癌前病变和宫颈癌的风险。方法/主要发现我们评估了416例宫颈上皮内瘤变3（CIN 3）/癌症病例中1113个基因的18，310个标签单核苷酸多态性（SNP），356名持续致癌HPV感染的妇女（中位持续时间为25个月）和425名随机选择的女性来自哥斯达黎加瓜纳卡斯特HPV自然史队列的10，049名妇女的HPV感染（非病例和非HPV持续性）。对于基因和SNP关联，我们计算了年龄调整的比值比和p趋势。进行了三项比较：1）与CIN 3/癌症的关联（将CIN 3/癌症病例与随机对照进行比较），2）与持续性的关联（将HPV持续性与随机对照进行比较），以及3）进展（将CIN 3/癌症与HPV持续性组进行比较）。与CIN 3/癌症统计学显著相关的区域包括过氧化物氧还蛋白3 PRDX 3和核糖体蛋白S19 RPS 19的基因。来自与CIN 3/癌症相关的每个基因的单个最显著SNP分别是PRDX 3 rs7082598（P趋势<0.0001）和RPS 19 rs 2305809（P趋势=0.0007）。这两个SNP也与进展相关。结论/意义这些数据表明，两个基因，RSP 19和PRDX 3，或其他SNPs的连锁不平衡参与，与宫颈癌的风险。进一步的研究表明，它们可能参与了持续和进展的过渡阶段。我们的研究结果需要复制，但如果是真的，表明核糖体功能障碍，线粒体过程，和/或氧化应激，或其他未知的功能，这些基因在宫颈癌的作用。
Background Host genetic factors might affect the risk of progression from infection with carcinogenic human papillomavirus (HPV), the etiologic agent for cervical cancer, to persistent HPV infection, and hence to cervical precancer and cancer. Methodology/Principal Findings We assessed 18,310 tag single nucleotide polymorphisms (SNPs) from 1113 genes in 416 cervical intraepithelial neoplasia 3 (CIN3)/cancer cases, 356 women with persistent carcinogenic HPV infection (median persistence of 25 months) and 425 randomly selected women (non-cases and non-HPV persistent) from the 10,049 women from the Guanacaste, Costa Rica HPV natural history cohort. For gene and SNP associations, we computed age-adjusted odds ratio and p-trend. Three comparisons were made: 1) association with CIN3/cancer (compared CIN3/cancer cases to random controls), 2) association with persistence (compared HPV persistence to random controls), and 3) progression (compared CIN3/cancers with HPV-persistent group). Regions statistically significantly associated with CIN3/cancer included genes for peroxiredoxin 3 PRDX3, and ribosomal protein S19 RPS19. The single most significant SNPs from each gene associated with CIN3/cancer were PRDX3 rs7082598 (P trend<0.0001), and RPS19 rs2305809 (P trend=0.0007), respectively. Both SNPs were also associated with progression. Conclusions/Significance These data suggest involvement of two genes, RSP19 and PRDX3, or other SNPs in linkage disequilibrium, with cervical cancer risk. Further investigation showed that they may be involved in both the persistence and progression transition stages. Our results require replication but, if true, suggest a role for ribosomal dysfunction, mitochondrial processes, and/or oxidative stress, or other unknown function of these genes in cervical carcinogenesis.
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DOI：
10.1086/595563
发表时间：
2009-01-01
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Wang SS;Bratti MC;Rodríguez AC;Herrero R;Burk RD;Porras C;González P;Sherman ME;Wacholder S;Lan ZE;Schiffman M;Chanock SJ;Hildesheim A
通讯作者：
Hildesheim A
影响因子：
6.4
作者：
Czene, K;Lichtenstein, P;Hemminki, K
通讯作者：
Hemminki, K
影响因子：
6.4
作者：
Wang, SS;Hildesheim, A;Carrington, M
通讯作者：
Carrington, M
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
6.4
作者：
Hussain, Shehnaz K.;Sundquist, Jan;Hemminki, Kari
通讯作者：
Hemminki, Kari