Clinicopathological Characteristics of Inflammatory Myositis Induced by COVID-19 Vaccine (Pfizer-BioNTech BNT162b2): A Case Report.
Clinicopathological Characteristics of Inflammatory Myositis Induced by COVID-19 Vaccine (Pfizer-BioNTech BNT162b2): A Case Report.
复制标题
DOI：
10.3346/jkms.2022.37.e91
复制
发表时间：
2022-03-21
影响因子：
4.5
通讯作者：
Woo CG
中科院分区：
文献类型：
--
作者：
Kim JH;Kim JH;Woo CG
随着越来越多的人接种 2019 年冠状病毒病 (COVID-19) 疫苗，出现了意想不到的副作用。在此，我们介绍了一名 30 岁男性在注射第二剂辉瑞 BioNTech (BNT162b2) COVID-19 疫苗后双肢出现肌病的病例。症状表现为肿胀和疼痛，从上肢和下肢的近端开始，延伸到远端。尽管他进行了大量的补水，但肌酶水平却不断增加。他主诉吞咽困难和构音障碍。显微镜下，肌肉活检显示多灶性或分散性巨噬细胞浸润和肌纤维退化。与包括炎性肌炎和横纹肌溶解在内的一般肌病相比，疫苗诱导的炎性肌炎表现出肌酶水平长期升高和多灶性巨噬细胞浸润并伴有肌纤维坏死。糖皮质激素和免疫抑制治疗可改善症状。如果接种疫苗的人出现严重且持续的肌肉疼痛和肿胀，临床医生应考虑疫苗引起的炎性肌炎，测量肌酶水平，并进行肌肉活检以明确诊断。
As more individuals were coronavirus disease 2019 (COVID-19) vaccinated, unexpected side effects appeared. Herein, we present the case of a 30-year-old man with myopathy in both extremities after the second dose of the Pfizer-BioNTech (BNT162b2) COVID-19 vaccine. Symptoms, swelling and pain, started from the proximal upper and lower extremities and extended to the distal parts. Although he underwent massive hydration, the muscle enzyme level continuously increased. He complained of dysphagia and dysarthria. Microscopically, muscle biopsy showed multifocal or scattered macrophage infiltration and degenerated myofibers. In contrast to general myopathy including inflammatory myositis and rhabdomyolysis, vaccine-induced inflammatory myositis shows a prolonged increase in muscle enzyme levels and multifocal macrophage infiltration with necrosis of the muscle fibers. Symptoms improved with glucocorticoid and immunosuppressive treatment. If vaccinated individuals experience severe and continuous muscle pain and swelling, clinicians should consider vaccine-induced inflammatory myositis, measure the muscle enzyme levels, and perform muscle biopsy for a definite diagnosis.
登录
查看更多内容
BNT162B2 mRNA COVID-19疫苗的安全性和功效。
DOI：
10.1056/nejmoa2034577
发表时间：
2020-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Polack FP;Thomas SJ;Kitchin N;Absalon J;Gurtman A;Lockhart S;Perez JL;Pérez Marc G;Moreira ED;Zerbini C;Bailey R;Swanson KA;Roychoudhury S;Koury K;Li P;Kalina WV;Cooper D;Frenck RW Jr;Hammitt LL;Türeci Ö;Nell H;Schaefer A;Ünal S;Tresnan DB;Mather S;Dormitzer PR;Şahin U;Jansen KU;Gruber WC;C4591001 Clinical Trial Group
通讯作者：
C4591001 Clinical Trial Group
DOI：
10.1016/j.dsx.2021.06.007
发表时间：
2021-07
期刊：
Diabetes & metabolic syndrome
影响因子：
--
作者：
Nassar M;Chung H;Dhayaparan Y;Nyein A;Acevedo BJ;Chicos C;Zheng D;Barras M;Mohamed M;Alfishawy M;Nso N;Rizzo V;Kimball E
通讯作者：
Kimball E
影响因子：
4.5
作者：
Kim G;Choi EJ;Park HS;Lee JH;Lee JH;Lee KH
通讯作者：
Lee KH
DOI：
10.3390/v12111289
发表时间：
2020-11-11
期刊：
Viruses
影响因子：
--
作者：
Wang L;Xiang Y
通讯作者：
Xiang Y
影响因子：
3.3
作者：
Schmidt J
通讯作者：
Schmidt J