Dendritic cells: novel players in fibrosis and scleroderma.

Dendritic cells: novel players in fibrosis and scleroderma.
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DOI:
10.1007/s11926-011-0215-5
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发表时间:
2012-02
影响因子:
5
通讯作者:
Lu TT
Lu TT
中科院分区:
医学2区
文献类型:
--
作者:
Lu TT

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树突状细胞是专职的抗原呈递细胞,其在介导T细胞耐受和T细胞活化中的功能被研究得最多。此外,最近的证据表明,树突状细胞可以调节成纤维细胞型细胞的血管和功能。树突状细胞对硬皮病和纤维化的潜在作用还不清楚。在这篇文章中,我们回顾了最近的研究,并描述了我们自己正在进行的工作,指出树突状细胞在硬皮病和纤维化中的作用。
Dendritic cells are professional antigen-presenting cells that are most studied for their function in mediating T-cell tolerance and T-cell activation. In addition, recent evidence indicates that dendritic cells can regulate the vasculature and function of fibroblast-type cells. The potential contribution of dendritic cells to scleroderma and fibrosis is not well-understood. In this article, we review recent studies as well as describe our own ongoing work that points toward a role for dendritic cells in scleroderma and fibrosis.
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