Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression.
Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression.
复制标题
Linc-ROR 通过调节 DEPDC1 表达促进肝细胞癌的进展和血管生成
DOI：
10.1038/s41419-021-04303-5
复制
发表时间：
2021-11-05
影响因子：
9
通讯作者：
Wang R
中科院分区：
文献类型：
--
作者：
Tian C;Abudoureyimu M;Lin X;Chu X;Wang R
Linc-ROR have been well-demonstrated to play important roles in cancer progression and angiogenesis. However, the underlying oncogenic mechanism of Linc-ROR in hepatocellular carcinoma is poorly understood. In this study, we demonstrate that Linc-ROR plays an oncogenic role in part through its positive regulation of DEPDC1 expression. Mechanistically, Linc-ROR acts as competing endogenous RNA to stabilize DEPDC1 mRNA and regulates DEPDC1 mRNA stability by binding HNRNPK. Thus, these findings suggest that function of Linc-ROR-mediated DEPDC1 could predispose hepatocellular carcinoma patients to progression and angiogenesis, and may serve as a potential target for anticancer therapies.
登录
查看更多内容
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
14.9
作者：
Cook KB;Kazan H;Zuberi K;Morris Q;Hughes TR
通讯作者：
Hughes TR
影响因子：
11.2
作者：
Harada, Yosuke;Kanehira, Mitsugu;Katagiri, Toyomasa
通讯作者：
Katagiri, Toyomasa
影响因子：
14.9
作者：
Karagkouni, Dimitra;Paraskevopoulou, Maria D.;Hatzigeorgiou, Artemis G.
通讯作者：
Hatzigeorgiou, Artemis G.