Metabolomic imaging for human prostate cancer detection.
Metabolomic imaging for human prostate cancer detection.
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DOI：
10.1126/scitranslmed.3000513
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发表时间：
2010-01-27
影响因子：
17.1
通讯作者：
Cheng LL
中科院分区：
文献类型：
--
作者：
Wu CL;Jordan KW;Ratai EM;Sheng J;Adkins CB;Defeo EM;Jenkins BG;Ying L;McDougal WS;Cheng LL
As current radiological approaches cannot accurately localize prostate cancer in vivo, biopsies are conducted at random within prostates for at-risk patients, leading to high false-negative rates. Metabolomic imaging can map cancer-specific biomolecular profile values onto anatomical structures to direct biopsy. In this preliminary study, we evaluated five prostatectomy-removed whole prostates from biopsy-proven cancer patients on a 7 Tesla human, whole-body magnetic resonance scanner. Localized, multi-cross-sectional, multi-voxel magnetic resonance spectra were used to construct a malignancy index based on prostate cancer metabolomic profiles obtained from previous, intact tissue analyses by a 14 Tesla spectrometer. This calculated Malignancy Index shows linear correlation with lesion size (p<0.013) and demonstrates a 93–97% overall accuracy for detecting the presence of prostate cancer lesions.
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影响因子：
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通讯作者：
Villers, Arnauld
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Haas, Gabriel P.;Delongchamps, Nicolas Barry;de la Roza, Gustavo
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de la Roza, Gustavo
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Koutcher, Jason A.
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