At the heart of microbial conversations: endocannabinoids and the microbiome in cardiometabolic risk.
At the heart of microbial conversations: endocannabinoids and the microbiome in cardiometabolic risk.
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DOI：
10.1080/19490976.2021.1911572
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发表时间：
2021-01
期刊：
影响因子：
12.2
通讯作者：
R Naudin C
中科院分区：
文献类型：
--
作者：
Khan RN;Maner-Smith K;A Owens J;Barbian ME;M Jones R;R Naudin C
心脏代谢综合征包括相互交织的风险因素，如高血压、血脂异常、甘油三酯升高、腹部肥胖和其他适应不良的代谢和炎性畸变。随着心血管疾病和代谢紊乱的分子机制的研究，内源性大麻素已成为感兴趣的分子。生物活性脂质的内源性大麻素系统（ECS）与多种疾病有关，包括慢性肝病、骨质疏松症，最近还与心血管疾病有关。肠道微生物组是宿主中炎症和代谢信号的主要调节器，如果被破坏，有可能导致代谢和心血管疾病。广泛的研究已经揭示了肠道微生物组对宿主生理学的影响，最近的报告显示，肠道微生物精细地控制着ECS，对宿主代谢和心脏健康产生重大影响。在这篇综述中，我们概述了肠道微生物组的调节如何通过ECS影响宿主代谢和心血管健康，以及这些发现如何被用作各种代谢和心脏疾病的新治疗靶点。
Cardiometabolic syndrome encompasses intertwined risk factors such as hypertension, dyslipidemia, elevated triglycerides, abdominal obesity, and other maladaptive metabolic and inflammatory aberrations. As the molecular mechanisms linking cardiovascular disease and metabolic disorders are investigated, endocannabinoids have emerged as molecules of interest. The endocannabinoid system (ECS) of biologically active lipids has been implicated in several conditions, including chronic liver disease, osteoporosis, and more recently in cardiovascular diseases. The gut microbiome is a major regulator of inflammatory and metabolic signaling in the host, and if disrupted, has the potential to drive metabolic and cardiovascular diseases. Extensive studies have unraveled the impact of the gut microbiome on host physiology, with recent reports showing that gut microbes exquisitely control the ECS, with significant influences on host metabolic and cardiac health. In this review, we outline how modulation of the gut microbiome affects host metabolism and cardiovascular health via the ECS, and how these findings could be exploited as novel therapeutic targets for various metabolic and cardiac diseases.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
饮食脂肪酸的摄入和肠道菌群确定循环内源性大麻素的信号传导超出了体内脂肪的作用。
影响因子：
4.6
作者：
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通讯作者：
Veilleux A
影响因子：
4.8
作者：
D'Argenio, G;Valenti, M;Di Marzo, V
通讯作者：
Di Marzo, V
影响因子：
24.5
作者：
Cani PD;Possemiers S;Van de Wiele T;Guiot Y;Everard A;Rottier O;Geurts L;Naslain D;Neyrinck A;Lambert DM;Muccioli GG;Delzenne NM
通讯作者：
Delzenne NM
影响因子：
4.7
作者：
D'Argenio, Giuseppe;Petrosino, Stefania;Di Marzo, Vincenzo
通讯作者：
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