L-Carnosine Protects Against Deoxynivalenol-induced Oxidative Stress in Intestinal Stem Cells by Regulating the Keap1/Nrf2 Signaling Pathway.
L-Carnosine Protects Against Deoxynivalenol-induced Oxidative Stress in Intestinal Stem Cells by Regulating the Keap1/Nrf2 Signaling Pathway.
复制标题
L-肌肽通过调节 Keap1/Nrf2 信号通路来保护肠干细胞免受脱氧雪腐镰刀菌烯醇诱导的氧化应激。
DOI：
10.1002/mnfr.202100406
复制
发表时间：
2021-07
影响因子：
5.2
通讯作者：
Wang Xiu-Qi
中科院分区：
文献类型：
--
作者：
Zhou Jia-Yi;Lin Hua-Lin;Qin Ying-Chao;Li Xiang-Guang;Gao Chun-Qi;Yan Hui-Chao;Wang Xiu-Qi
SCOPE
The intestinal epithelium is nourished by various nutrients and subjected to persistent and widespread feed-derived mycotoxin stress. L-Carnosine (LC) has robust antioxidant activity; however, its role in protecting intestinal mucosa against deoxynivalenol (DON) is still unclear.
METHODS AND RESULTS
In this study, 300 mg/kg BW LC and 3 mg/kg BW DON were orally administered to mice either alone or in combination for 10 days to investigate the role of LC in protecting the intestine against DON. We found that LC alleviated the growth retardation of mice and repaired the damaged jejunal structure and barrier functions under DON exposure. LC rescued the intestinal stem cells (ISCs), increased the growth advantage in enteroids derived from jejunal crypts of mice in each group ex vivo, improved the proliferation and apoptosis of intestinal cells, and promotes ISC differentiation into absorptive cells, goblet cells, and Paneth cells. Furthermore, LC activated Nrf2 signaling by binding to Keap1 to reverse the striking DON-induced increase in ROS levels.
CONCLUSION
Our findings unveil that LC potentiates the antioxidant capacity of ISCs by regulating the Keap1/Nrf2 signaling pathway, which contributed to the intestinal epithelial regeneration response to DON insult. This article is protected by copyright. All rights reserved.
登录
查看更多内容
影响因子：
7.3
作者：
Al-Barazie RM;Bashir GH;Qureshi MM;Mohamed YA;Al-Sbiei A;Tariq S;Lammers WJ;Al-Ramadi BK;Fernandez-Cabezudo MJ
通讯作者：
Fernandez-Cabezudo MJ
肌肽抑制氧糖剥夺/恢复诱导的大鼠体外反应性星形胶质细胞的增殖和迁移
影响因子：
8.2
作者：
Li Ou-Yang;Liu, Yuan;Lyu, Jian-xin
通讯作者：
Lyu, Jian-xin
影响因子：
4.2
作者：
Gruber-Dorninger, Christiane;Jenkins, Timothy;Schatzmayr, Gerd
通讯作者：
Schatzmayr, Gerd
影响因子：
8.9
作者：
Kang, Ruifen;Li, Ruonan;Li, Chunmei
通讯作者：
Li, Chunmei
蛋氨酸及其羟基类似物通过重新激活 Wnt/β-连环蛋白信号传导改善干细胞活性，消除脱氧雪腐镰刀菌烯醇诱导的肠损伤
影响因子：
6.1
作者：
Jia-yi Zhou;Zhe Wang;Sai-wu Zhang;Hua-lin Lin;Chun-qi Gao;Jiang-chao Zhao;Chengbo Yang;Xiu-qi Wang
通讯作者：
Xiu-qi Wang