Role of aerobic glycolysis in genetically engineered mouse models of cancer.
Role of aerobic glycolysis in genetically engineered mouse models of cancer.
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DOI：
10.1186/1741-7007-11-3
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发表时间：
2013-01-23
期刊：
影响因子：
5.4
通讯作者：
Dang CV
中科院分区：
文献类型：
--
作者：
Dang CV
癌细胞通过有氧糖酵解将高水平的葡萄糖转化为乳酸的倾向已经在体外得到了深入的研究，现在被认为是一种代谢适应，将葡萄糖碳分流到生长细胞的构建块，以及产生ATP。然而，人们对体内有氧糖酵解和糖酵解酶的作用知之甚少。《癌症与新陈代谢》的一篇论文现在记录了正常新生小鼠小脑中增殖的神经前体细胞的有氧糖酵解，以及转基因小鼠从这些细胞衍生的髓母细胞瘤中的有氧糖酵解。己糖激酶II被证明是观察到的有氧糖酵解和肿瘤恶性的重要驱动因素。参见研究文章：http://www.cancerandmetabolism.com/content/1/1/2
The propensity of cancer cells to convert high levels of glucose to lactate through aerobic glycolysis has been intensively studied in vitro, and is now understood to be a metabolic adaptation that shunts glucose carbons toward building blocks for the growing cell, as well as producing ATP. Much less is known, however, about the role of aerobic glycolysis and glycolytic enzymes in vivo. A paper in Cancer and Metabolism now documents aerobic glycolysis in the proliferating neural progenitors that form the cerebellum in normal newborn mice, as well as in medulloblastoma tumors derived from these cells in transgenic mice. Hexokinase II is demonstrated to be an essential driver of the observed aerobic glycolysis and the malignancy of the tumors. See research article: http://www.cancerandmetabolism.com/content/1/1/2
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