Soluble Membrane Attack Complex: Biochemistry and Immunobiology.
Soluble Membrane Attack Complex: Biochemistry and Immunobiology.
复制标题
DOI：
10.3389/fimmu.2020.585108
复制
发表时间：
2020
影响因子：
7.3
通讯作者：
Schein TN
中科院分区：
文献类型：
--
作者：
Barnum SR;Bubeck D;Schein TN
可溶性膜攻击复合物（sMAC，a.k.a.，sC 5 b-9或TCC）在补体激活时产生，并含有补体蛋白C5 b、C6、C7、C8、C9以及调节蛋白丛生蛋白和/或玻连蛋白。sMAC是孔形成分子的MACPF/胆固醇依赖性溶细胞素超家族的成员，其插入脂质双层并破坏细胞完整性和功能。sMAC是一种独特的补体激活大分子，因为它由几种不同的亚基组成。迄今为止，尚未确定sMAC的补体介导功能。sMAC在体内平衡条件下存在于血液和其他体液中，并且有大量证据证明在感染、自身免疫性疾病和创伤期间sMAC水平的变化。尽管几十年来对sMAC的科学兴趣，但调节其在健康个体中形成的机制及其在健康和疾病中的生物学功能仍然知之甚少。在这里，我们回顾sMAC和它的膜对应，MAC之间的结构差异，并检查sMAC的免疫生物学在健康和疾病的体液中的存在。最后，我们讨论了sMAC的诊断和预后应用的诊断潜力和潜在的效用作为一个伴侣诊断。
The soluble membrane attack complex (sMAC, a.k.a., sC5b-9 or TCC) is generated on activation of complement and contains the complement proteins C5b, C6, C7, C8, C9 together with the regulatory proteins clusterin and/or vitronectin. sMAC is a member of the MACPF/cholesterol-dependent-cytolysin superfamily of pore-forming molecules that insert into lipid bilayers and disrupt cellular integrity and function. sMAC is a unique complement activation macromolecule as it is comprised of several different subunits. To date no complement-mediated function has been identified for sMAC. sMAC is present in blood and other body fluids under homeostatic conditions and there is abundant evidence documenting changes in sMAC levels during infection, autoimmune disease and trauma. Despite decades of scientific interest in sMAC, the mechanisms regulating its formation in healthy individuals and its biological functions in both health and disease remain poorly understood. Here, we review the structural differences between sMAC and its membrane counterpart, MAC, and examine sMAC immunobiology with respect to its presence in body fluids in health and disease. Finally, we discuss the diagnostic potential of sMAC for diagnostic and prognostic applications and potential utility as a companion diagnostic.
登录
查看更多内容
补体的膜攻击机制。在自由溶液中验证稳定的C5-9复合物。
影响因子：
15.3
作者：
Kolb, W P;Muller-Eberhard, H J
通讯作者：
Muller-Eberhard, H J
人类补体的末端膜C5B-9复合物：通过血清中S蛋白的结合从两亲性到亲水状态的过渡。
DOI：
10.1083/jcb.94.3.755
发表时间：
1982-09
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bhakdi S;Tranum-Jensen J
通讯作者：
Tranum-Jensen J
影响因子：
1.9
作者：
BAROHN, RJ;BREY, RL
通讯作者：
BREY, RL
影响因子：
2
作者：
Aly, Hany;Khashaba, Mohamed T.;Lassiter, Herbert A.
通讯作者：
Lassiter, Herbert A.
影响因子：
2.2
作者：
BHAKDI, S;MUHLY, M
通讯作者：
MUHLY, M