Autoimmune disease and COVID-19: a multicentre observational study in the United Kingdom.
Autoimmune disease and COVID-19: a multicentre observational study in the United Kingdom.
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DOI：
10.1093/rheumatology/keac209
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发表时间：
2022-11-28
期刊：
影响因子：
--
通讯作者：
CA-COVID-19 Study Group
中科院分区：
文献类型：
--
作者：
Arachchillage DJ;Rajakaruna I;Pericleous C;Nicolson PLR;Makris M;Laffan M;CA-COVID-19 Study Group
建立自身免疫性疾病（AD）患者的人口学特征、实验室结果和临床结果，并将其与英国入院的COVID-19非AD患者的倾向匹配队列进行比较。这是一项横跨26个NHS信托机构的多中心观察性研究。使用预先设计的标准化病例记录表格回顾性和前瞻性地收集数据。纳入2020年4月1日至2020年7月31日期间入院的成年患者（≥18岁）。总共有6288名患者参与了这项研究。其中，394名患者在感染COVID-19入院前患有AD。在394例患者中，80例SLE、RA或aPL综合征患者被归类为严重风湿病性AD。AD患者出现贫血的比例较高[240 (60.91%)vs 206 (52.28%), P = 0.015]， LDH升高[150 (38.08%)vs 43 (10.92%), P < 0.001]，肌酐升高[122 (30.96%)vs 86 (21.83%), P = 0.01]。严重风湿性AD患者CRP (77 （96.25%) vs 70 (87.5%), P = 0.044）和LDH (20 （25%) vs 6 (7.5%), P = 0.021）升高的比例明显更高。重度风湿性AD患者的死亡率[32/80(40%)]明显高于无AD患者的倾向匹配队列[20/80 (25%),P = 0.043]。然而，在一般AD患者与非AD患者的倾向匹配队列中，180天死亡率没有差异（P = 0.47）。严重的风湿性阿尔茨海默病患者的死亡率明显更高。贫血、肾功能损害和LDH升高在任何AD患者中都更为常见，而CRP和LDH升高在严重风湿性AD患者中更为常见，这两种情况都被证明与COVID-19患者死亡率增加有关。
To establish the demographic characteristics, laboratory findings and clinical outcomes in patients with autoimmune disease (AD) compared with a propensity-matched cohort of patients without AD admitted with COVID-19 to hospitals in the UK. This is a multicentre observational study across 26 NHS Trusts. Data were collected both retrospectively and prospectively using a predesigned standardized case record form. Adult patients (≥18 years) admitted between 1 April 2020 and 31 July 2020 were included. Overall, 6288 patients were included to the study. Of these, 394 patients had AD prior to admission with COVID-19. Of 394 patients, 80 patients with SLE, RA or aPL syndrome were classified as severe rheumatologic AD. A higher proportion of those with AD had anaemia [240 (60.91%) vs 206 (52.28%), P = 0.015], elevated LDH [150 (38.08%) vs 43 (10.92%), P < 0.001] and raised creatinine [122 (30.96%) vs 86 (21.83%), P = 0.01], respectively. A significantly higher proportion of patients with severe rheumatologic AD had elevated CRP [77 (96.25%) vs 70 (87.5%), P = 0.044] and LDH [20 (25%) vs 6 (7.5%), P = 0.021]. Patients with severe rheumatologic AD had significantly higher mortality [32/80 (40%)] compared with propensity matched cohort of patients without AD [20/80 (25%), P = 0.043]. However, there was no difference in 180-day mortality between propensity-matched cohorts of patients with or without AD in general (P = 0.47). Patients with severe rheumatologic AD had significantly higher mortality. Anaemia, renal impairment and elevated LDH were more frequent in patients with any AD while elevated CRP and LDH were more frequent in patients with severe rheumatologic AD both of which have been shown to associate with increased mortality in patients with COVID-19.
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影响因子：
2.9
作者：
Hodges G;Pallisgaard J;Schjerning Olsen AM;McGettigan P;Andersen M;Krogager M;Kragholm K;Køber L;Gislason GH;Torp-Pedersen C;Bang CN
通讯作者：
Bang CN
影响因子：
12.8
作者：
Zen M;Fuzzi E;Astorri D;Saccon F;Padoan R;Ienna L;Cozzi G;Depascale R;Zanatta E;Gasparotto M;Benvenuti F;Bindoli S;Gatto M;Felicetti M;Ortolan A;Campaniello D;Larosa M;Lorenzin M;Ramonda R;Sfriso P;Schiavon F;Iaccarino L;Doria A
通讯作者：
Doria A
影响因子：
25.4
作者：
Zhong, Jixin;Shen, Guifen;Dong, Lingli
通讯作者：
Dong, Lingli
影响因子：
10.4
作者：
Schulman, S;Kearon, C
通讯作者：
Kearon, C
影响因子：
27.4
作者：
Pablos, Jose L.;Galindo, Maria;Fernandez-Nebro, Antonio
通讯作者：
Fernandez-Nebro, Antonio