SARS-CoV-2 infection in patients with autoimmune rheumatic diseases in northeast Italy: A cross-sectional study on 916 patients.
SARS-CoV-2 infection in patients with autoimmune rheumatic diseases in northeast Italy: A cross-sectional study on 916 patients.
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DOI：
10.1016/j.jaut.2020.102502
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发表时间：
2020-08
影响因子：
12.8
通讯作者：
Doria A
中科院分区：
文献类型：
--
作者：
Zen M;Fuzzi E;Astorri D;Saccon F;Padoan R;Ienna L;Cozzi G;Depascale R;Zanatta E;Gasparotto M;Benvenuti F;Bindoli S;Gatto M;Felicetti M;Ortolan A;Campaniello D;Larosa M;Lorenzin M;Ramonda R;Sfriso P;Schiavon F;Iaccarino L;Doria A
自身免疫性风湿性疾病（ARD）患者是否有更高的SARS-CoV-2感染（COVID-19）风险，以及SARS-CoV-2大流行如何影响治疗依从性尚未完全阐明。我们评估了意大利东北部一所三级大学医院随访的大型ARD患者队列中COVID-19的发病率和临床表现以及治疗依从性。2020年4月9日至4月25日，在SARS-CoV-2感染高峰后，进行了一项电话调查，调查COVID-19对系统性红斑狼疮（SLE）、系统性硬化症（SSc）、类风湿性关节炎（RA）、ANCA相关血管炎（AAV）和特发性炎性肌病（IIM）患者的影响。人口统计学，疾病活动状态，治疗，职业暴露，并遵守社会距离的建议。916例患者（397例SLE，182例AAV，176例SSc，111例RA，50例IIM）完成了调查。148名患者出现了至少一种与COVID-19相符的症状（咳嗽96例、咽喉痛64例、发热64例、关节肌痛59例、腹泻26例、结膜炎18例、味觉丧失/嗅觉减退18例）。在916例患者中，65例（7.1%）接受了SARS-CoV-2鼻咽拭子（18例有症状，47例无症状），2例（0.21%）检测阳性，这一比例与韦内托地区一般人群中观察到的比例相似。未发生死亡。31例患者（3.4%）停用≥1种药物，主要是免疫抑制剂或生物制剂。860名患者（93.9%）采用了社交距离，其中335名（36.6%）在官方封锁前采用了社交距离。与一般人群相比，我们队列中的COVID-19发病率似乎相似。坚持治疗和社会距离的建议是很高的。ARDs中SARS-CoV-2感染率似乎与一般人群相似。不同的ARD组普遍采用社交距离措施。早期社交距离在接受多种药物治疗的未缓解患者中更为常见。由于COVID相关问题而停止治疗的情况很少见，但即使是活跃的患者也会这样做。在我们的队列中，基于≥3种药物的治疗方案与治疗中止相关。
Whether patients with autoimmune rheumatic diseases (ARD) have a higher risk for SARS-CoV-2 infection (COVID-19) and how SARS-CoV-2 pandemic impacts on adherence to therapy has not been fully elucidated. We assessed the rate and clinical presentation of COVID-19, and adherence to therapy in a large cohort of patients with ARD followed-up in a tertiary University-Hospital in Northeast Italy. Between April 9th and April 25th, 2020, after SARS-CoV-2 infection peak, a telephone survey investigating the impact of COVID-19 on patients with systemic lupus erythematosus (SLE), systemic sclerosis (SSc), rheumatoid arthritis (RA), ANCA-associated vasculitis (AAV), and idiopathic inflammatory myopathies (IIM) was administered. Demographics, disease activity status, therapy, occupational exposure, and adherence to social distancing advise were also collected. 916 patients (397 SLE, 182 AAV, 176 SSc, 111 RA, 50 IIM) completed the survey. 148 patients developed at least one symptom compatible with COVID-19 (cough 96, sore throat 64, fever 64, arthromyalgias 59, diarrhea 26, conjunctivitis 18, ageusia/hyposmia, 18). Among the 916 patients, 65 (7.1%) underwent SARS-CoV-2 nasopharyngeal swab (18 symptomatic and 47 asymptomatic), 2 (0.21%) tested positive, a proportion similar to that observed in the general population of the Veneto region. No deaths occurred. 31 patients (3.4%) withdrew ≥1 medication, mainly immunosuppressants or biologics. Adoption of social distancing was observed by 860 patients (93.9%), including 335 (36.6%) who adopted it before official lockdown. COVID-19 incidence seems to be similar in our cohort compared to the general population. Adherence to therapy and to social distancing advise was high. SARS-CoV-2 infection rate in ARDs seems to be similar to that of the general population. Adoption of social distancing measures was prevalent among different ARD groups. Earlier social distancing was more common in unremitted patients, treated with multiple drugs. Therapy discontinuation due to COVID-related concerns was rare, but undertaken even by active patients. Therapeutic regimens based on ≥3 drugs were associated with therapy discontinuation in our cohort.
影响因子：
27.4
作者：
Lu, Chenyang;Li, Shasha;Liu, Yi
通讯作者：
Liu, Yi
影响因子：
168.9
作者：
Chen, Nanshan;Zhou, Min;Zhang, Li
通讯作者：
Zhang, Li
影响因子：
1.2
作者：
Morettini, Micaela;Sbrollini, Agnese;Burattini, Laura
通讯作者：
Burattini, Laura