Restoration of bilateral motor coordination from preserved agonist-antagonist coupling in amputation musculature.
Restoration of bilateral motor coordination from preserved agonist-antagonist coupling in amputation musculature.
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DOI：
10.1186/s12984-021-00829-z
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发表时间：
2021-02-17
影响因子：
5.1
通讯作者：
Herr HM
中科院分区：
文献类型：
--
作者：
Shu T;Huang SS;Shallal C;Herr HM
由于用户输出精确控制信号的能力和控制系统根据这些信号制定动态轨迹的能力的限制，由具有标准肢体截肢的人控制的神经假体装置通常缺乏生理肢体的灵活性。为了恢复截肢者的全肢功能，有必要首先推断和量化缺失肢体的运动性能，然后通过神经假体装置的直接、意志控制来满足这些性能要求。我们开发了一种神经肌肉建模和优化范式的激动剂拮抗剂肌神经接口，一种新的组织架构和神经接口的控制肌电假肢，使其能够生成虚拟关节轨迹协调完整的生物关节在生理相关的运动带宽。在本研究中，首先在非截肢对照受试者人群中建立性能基线（）。然后，先进的神经肌肉建模和优化技术，允许单侧AMI截肢受试者（）和标准截肢受试者（）使用受影响腿部残端内肌肉组织产生的测量表面肌电图（sEMG）信号生成虚拟距下假肢关节运动学。在仅具有本体感觉反馈的盲眼条件下使用其优化的神经肌肉距下模型，AMI截肢受试者显示出双侧距下协调准确性与非截肢者对照组没有显著差异（Kolmogorov-Smirnov检验），而标准截肢受试者显示出显著较差的性能（Kolmogorov-Smirnov检验）。这些结果表明，一个完整的生物关节的情况下，并不一定会删除产生足够的信息，以重建生理运动的神经物理信号的能力。此外，虚拟和完整的生物关节被示出为协调的无缝方式加强了这样的理论，即期望的运动轨迹在不依赖于物理肢体配置的抽象任务空间中被精神地制定。在线版本包含补充材料，可通过10.1186/s12984-021-00829-z获得。
Neuroprosthetic devices controlled by persons with standard limb amputation often lack the dexterity of the physiological limb due to limitations of both the user’s ability to output accurate control signals and the control system’s ability to formulate dynamic trajectories from those signals. To restore full limb functionality to persons with amputation, it is necessary to first deduce and quantify the motor performance of the missing limbs, then meet these performance requirements through direct, volitional control of neuroprosthetic devices. We develop a neuromuscular modeling and optimization paradigm for the agonist-antagonist myoneural interface, a novel tissue architecture and neural interface for the control of myoelectric prostheses, that enables it to generate virtual joint trajectories coordinated with an intact biological joint at full physiologically-relevant movement bandwidth. In this investigation, a baseline of performance is first established in a population of non-amputee control subjects (). Then, a neuromuscular modeling and optimization technique is advanced that allows unilateral AMI amputation subjects () and standard amputation subjects () to generate virtual subtalar prosthetic joint kinematics using measured surface electromyography (sEMG) signals generated by musculature within the affected leg residuum. Using their optimized neuromuscular subtalar models under blindfolded conditions with only proprioceptive feedback, AMI amputation subjects demonstrate bilateral subtalar coordination accuracy not significantly different from that of the non-amputee control group (Kolmogorov-Smirnov test, ) while standard amputation subjects demonstrate significantly poorer performance (Kolmogorov-Smirnov test, ). These results suggest that the absence of an intact biological joint does not necessarily remove the ability to produce neurophysical signals with sufficient information to reconstruct physiological movements. Further, the seamless manner in which virtual and intact biological joints are shown to coordinate reinforces the theory that desired movement trajectories are mentally formulated in an abstract task space which does not depend on physical limb configurations. The online version contains supplementary material available at 10.1186/s12984-021-00829-z.
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影响因子：
1.4
作者：
Buchanan, TS;Lloyd, DG;Besier, TF
通讯作者：
Besier, TF
影响因子：
5.7
作者：
Au, Samuel K.;Herr, Hugh M.
通讯作者：
Herr, Hugh M.
影响因子：
17.1
作者：
Clites, Tyler R.;Carty, Matthew J.;Herr, Hugh. M.
通讯作者：
Herr, Hugh. M.
影响因子：
6.8
作者：
HOGAN, N
通讯作者：
HOGAN, N
DOI：
10.1109/tnsre.2009.2039620
发表时间：
2010-04-01
影响因子：
4.9
作者：
Eilenberg, Michael F.;Geyer, Hartmut;Herr, Hugh
通讯作者：
Herr, Hugh