A comparison of fundus autofluorescence and retinal structure in patients with Stargardt disease.
A comparison of fundus autofluorescence and retinal structure in patients with Stargardt disease.
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Stargardt疾病患者的眼底自动荧光和视网膜结构的比较。
DOI：
10.1167/iovs.08-2657
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发表时间：
2009-08
影响因子：
4.4
通讯作者：
Chang S
中科院分区：
文献类型：
--
作者：
Gomes NL;Greenstein VC;Carlson JN;Tsang SH;Smith RT;Carr RE;Hood DC;Chang S
通过比较光谱域光学相干断层扫描（SD-OCT）与眼底自发荧光（FAF）上可见的结构变化，提高我们对Stargardt病的理解。对11例Stargardt病患者的22只眼进行了FAF和SD-OCT检查。在中心凹和偏心首选视网膜位点（PRL）处获得SD-OCT图像。测量“不存在”（低自发荧光）和“异常”FAF区域的直径。在中心凹区域测量光感受器的内段和外段（IS-OS）之间的连接的横向缺陷的程度。采用眼底照相和微视野检查评价PRL。22只眼中有21只眼显示FAF缺陷。17只眼FAF在中心凹内消失，4只眼FAF异常。SD-OCT显示所有患眼的中心凹区IS-OS连接紊乱和/或缺失，FAF缺失区直径小于IS-OS连接缺失区直径，后者更接近FAF异常区直径。17只眼睛有一个偏心的PRL与视网膜区没有缺陷的FAF。对于大多数眼睛，SD-OCT的变化与FAF的变化相关性良好。然而，对于3名患者，在SD-OCT上在中央凹中观察到感光细胞异常，而在FAF上没有等同的异常。这表明，对于这些患者，光感受器的结构完整性可能比RPE的变化更早受到影响，至少如FAF所检测到的。
To improve our understanding of Stargardt disease by comparing structural changes seen on spectral domain optical coherence tomography (SD-OCT) to those visible on fundus autofluorescence (FAF). FAF and SD-OCT were obtained on 22 eyes of 11 patients with Stargardt disease. SD-OCT images were obtained at the fovea and at the eccentric preferred retinal locus (PRL). The diameters of “absent” (hypo-autofluorescent) and “abnormal” FAF areas were measured. The extent of the transverse defect of the junction between the inner and outer segments of the photoreceptors (IS-OS) was measured in the foveal area. The PRL was evaluated with fundus photography and microperimetry. Twenty-one of 22 eyes showed defective FAF. For 17 eyes, FAF was absent in the fovea and for 4 eyes the FAF was abnormal. All eyes showed disorganization and/or loss of the IS-OS junction in the foveal area on SD-OCT. The diameter of the absent FAF area was smaller than the measurement of the IS-OS junction loss; the latter was closer to the diameter of the abnormal FAF area. Seventeen eyes had an eccentric PRL associated with a retinal area with no defects on FAF. For the majority of eyes changes on SD-OCT correlated well with changes on FAF. However for 3 patients, photoreceptor abnormalities were seen in the fovea on SD-OCT without an equivalent abnormality on FAF. This suggests that for these patients, the structural integrity of the photoreceptors may be affected earlier than changes in the RPE at least as detected by FAF.
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DOI：
10.1089/109065700316408
发表时间：
2000-03-01
期刊：
GENETIC TESTING
影响因子：
--
作者：
Kurg, A;Tonisson, N;Metspalu, A
通讯作者：
Metspalu, A
影响因子：
13.7
作者：
Ko, TH;Fujimoto, JG;Duker, JS
通讯作者：
Duker, JS
影响因子：
4.4
作者：
Zernant, J;Külm, M;Allikmets, R
通讯作者：
Allikmets, R
影响因子：
4.1
作者：
Murdoch, IE;Morris, SS;Cousens, SN
通讯作者：
Cousens, SN
影响因子：
4.4
作者：
Rohrschneider, K
通讯作者：
Rohrschneider, K