The relationship between maternal psychopathology and offspring incontinence and constipation at school age: a prospective cohort study
The relationship between maternal psychopathology and offspring incontinence and constipation at school age: a prospective cohort study
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母亲精神病理学与后代学龄尿失禁和便秘之间的关系：一项前瞻性队列研究
DOI：
10.1101/2022.12.07.22283220
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Sawyer G
中科院分区：
文献类型：
--
作者：
Sawyer G
背景：有证据表明母亲精神病理与子女尿失禁和便秘之间存在关联，但尚不清楚产前或产后是否存在母亲抑郁和/或焦虑暴露的关键/敏感期。来自雅芳父母和儿童纵向研究的母亲提供了他们的抑郁和焦虑（产前和产后）以及他们的孩子在7岁时尿失禁和便秘的数据（6489名参与者）。我们使用多变量逻辑回归来检验母亲抑郁/焦虑对后代尿失禁/便秘的独立影响的证据，并调查是否存在暴露的关键/敏感期。我们使用阴性对照设计检查子宫内因果效应的证据。结果产后母亲精神病理与后代尿失禁和便秘的风险增加相关（如产后焦虑和白天尿床OR: 1.53; 95% CI: 1.21-1.94）。数据与产后关键时期模型一致，有证据表明母亲焦虑的独立影响。产前母亲精神病理与子代便秘有关（如产前焦虑OR: 1.57; 95% CI: 1.25-1.98），但没有证据表明子宫内存在因果关系。局限性没有使用尿失禁/便秘诊断标准的营养和产妇报告是潜在的局限性。结论暴露于母亲产后精神病理环境下的儿童出现尿失禁/便秘的风险较大，且母亲焦虑的相关性强于抑郁。卫生专业人员应警惕母亲精神病理对儿童发育的影响。需要确定将母亲精神病理与儿童尿失禁/便秘联系起来的机制，以提供基于证据的支持。
BackgroundThere is evidence for an association between maternal psychopathology and offspring incontinence and constipation, but it is unclear if there is a critical/sensitive period of exposure to maternal depression and/or anxiety in the antenatal or postnatal period.MethodsMothers from the Avon Longitudinal Study of Parents and Children provided data on their depression and anxiety (antenatal and postnatal) and their child's urinary and faecal incontinence and constipation at age 7 (6489 participants). We used multivariable logistic regression to examine evidence for independent effects of maternal depression/anxiety on offspring incontinence/constipation and to investigate if there was a critical/sensitive period of exposure. We examined evidence for causal intra-uterine effects using a negative control design.ResultsPostnatal maternal psychopathology was associated with an increased risk of offspring incontinence and constipation (e.g. postnatal anxiety and daytime wetting OR: 1.53; 95 % CI: 1.21–1.94). Data were consistent with a postnatal critical period model and there was evidence for an independent effect of maternal anxiety. Antenatal maternal psychopathology was associated with offspring constipation (e.g. antenatal anxiety OR: 1.57; 95 % CI: 1.25–1.98), but there was no evidence for a causal intra-uterine effect.LimitationsAttrition and maternal reports without use of diagnostic criteria for incontinence/constipation are potential limitations.ConclusionsChildren exposed to maternal postnatal psychopathology had a greater risk of incontinence/constipation, and maternal anxiety had stronger associations than depression. Health professionals should be vigilant to effects of maternal psychopathology on child development. Identification of mechanisms linking maternal psychopathology to child incontinence/constipation is required to inform evidence-based support.
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影响因子：
1.4
作者：
D. Akdemir;S. E. Çengel Kültür;İ. S. Saltık Temizel;A. Zeki;G. Şenses Dinç
通讯作者：
G. Şenses Dinç
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影响因子：
3.3
作者：
Denise M. Mota;A. Barros
通讯作者：
A. Barros
影响因子：
6.6
作者：
Edmondson, Olivia J. H.;Psychogiou, Lamprini;Vlachos, Haido;Netsi, Elena;Ramchandani, Paul G.
通讯作者：
Ramchandani, Paul G.
原发性夜间遗尿症儿童母亲的精神状况：一项对照研究。
影响因子：
2
作者：
O. Durmaz;S. Kemer;T. Mutluer;Elif Bütün
通讯作者：
Elif Bütün
DOI：
10.1016/j.jaac.2016.12.007
发表时间：
2017-03
影响因子：
13.3
作者：
Kessel EM;Allmann AE;Goldstein BL;Finsaas M;Dougherty LR;Bufferd SJ;Carlson GA;Klein DN
通讯作者：
Klein DN