Angioedema: clinical and etiological aspects.

Angioedema: clinical and etiological aspects.
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DOI:
10.1155/2007/26438
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发表时间:
2007
影响因子:
--
通讯作者:
Jongjarearnprasert, Kowit
Jongjarearnprasert, Kowit
中科院分区:
其他
文献类型:
--
作者:
Kulthanan, Kanokvalai;Jiamton, Sukhum;Boochangkool, Kanonrat;Jongjarearnprasert, Kowit

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血管性水肿是皮肤、粘膜或两者(包括呼吸道和胃肠道)的突然肿胀。本研究旨在报告一所大学医院血管性水肿的病因、临床特征、治疗和结局。105例患者入组。大约一半的人有血管性水肿,没有荨麻疹。好发部位为眶周及唇部。45例患者(49%)有全身症状。血管性水肿最常见的原因是过敏性血管性水肿。非甾体抗炎药诱导的血管性水肿和特发性血管性水肿分别为20%和18%。过敏性血管性水肿的病因中,食物引起的占41.7%,药物引起的占39.6%。37例患者(39%)有血管性水肿复发。复发性血管性水肿患者的平均标准差(SD)发作次数为3.9(2.7)次(范围为2 - 10次)。年龄较大且皮肤累及多个部位的患者倾向于出现全身症状。
Angioedema is an abrupt swelling of the skin, mucous membrane, or both including respiratory and gastrointestinal tracts. This study aimed to report an experience of angioedema in a university hospital with respect to etiologies, clinical features, treatment, and outcome. One hundred and five patients were enrolled. About half had angioedema without urticaria. The common sites of involvement were periorbital area and lips. Forty five patients (49%) had systemic symptoms. The most common cause of angioedema was allergic angioedema. Nonsteroidal anti-inflammatory drug-induced angioedema and idiopathic angioedema were detected in 20% and 18%, respectively. Among patients with allergic angioedema, 41.7% were caused by food, 39.6% by drugs. Thirty seven patients (39%) had recurrent attacks of angioedema. Mean standard deviation (SD) number of attacks in patients with recurrent angioedema was 3.9 (2.7) (ranging from 2 to 10 times). Patients who had older age and multiple sites of skin involvement had tendency to have systemic symptoms.
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