Debra-mediated Ci degradation controls tissue homeostasis in Drosophila adult midgut.
Debra-mediated Ci degradation controls tissue homeostasis in Drosophila adult midgut.
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Debra 介导的 Ci 降解控制果蝇成年中肠的组织稳态。
DOI：
10.1016/j.stemcr.2013.12.011
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发表时间：
2014-02-11
影响因子：
5.9
通讯作者：
Lin, Xinhua
中科院分区：
文献类型：
--
作者：
Li, Zhouhua;Guo, Yueqin;Han, Lili;Zhang, Yan;Shi, Lai;Huang, Xudong;Lin, Xinhua
Adult tissue homeostasis is maintained by resident stem cells and their progeny. However, the underlying mechanisms that control tissue homeostasis are not fully understood. Here, we demonstrate that Debra-mediated Ci degradation is important for intestinal stem cell (ISC) proliferation in Drosophila adult midgut. Debra inhibition leads to increased ISC activity and tissue homeostasis loss, phenocopying defects observed in aging flies. These defects can be suppressed by depleting Ci, suggesting that increased Hedgehog (Hh) signaling contributes to ISC proliferation and tissue homeostasis loss. Consistently, Hh signaling activation causes the same defects, whereas depletion of Hh signaling suppresses these defects. Furthermore, the Hh ligand from multiple sources is involved in ISC proliferation and tissue homeostasis. Finally, we show that the JNK pathway acts downstream of Hh signaling to regulate ISC proliferation. Together, our results provide insights into the mechanisms of stem cell proliferation and tissue homeostasis control. Dbr regulates ISC proliferation and midgut homeostasis in Drosophila adult midgut Dbr controls ISC proliferation through Ci Elevated Hh signaling induces ISC proliferation Cytoprotective JNK signaling acts downstream of Hh signaling in ISC proliferation Adult tissue homeostasis is maintained by resident stem cells and their progeny. However, the underlying mechanisms that control tissue homeostasis are not fully understood. Lin and colleagues demonstrate that Debra-mediated Ci degradation is important for intestinal stem cell proliferation in Drosophila adult midgut. Their results provide insights into the mechanisms of stem cell proliferation and tissue homeostasis control.
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影响因子：
23.9
作者：
Jiang H;Grenley MO;Bravo MJ;Blumhagen RZ;Edgar BA
通讯作者：
Edgar BA
影响因子：
11.8
作者：
Jiang J;Hui CC
通讯作者：
Hui CC
气管衍生的 dpp 控制果蝇成年中肠稳态。
影响因子：
11.8
作者：
Li, Zhouhua;Zhang, Yan;Lin, Xinhua
通讯作者：
Lin, Xinhua
影响因子：
9.2
作者：
Furriols, M;Bray, S
通讯作者：
Bray, S
影响因子：
11.8
作者：
Dai, P;Akimaru, H;Ishii, S
通讯作者：
Ishii, S