Positive Epstein-Barr virus detection in coronavirus disease 2019 (COVID-19) patients.
Positive Epstein-Barr virus detection in coronavirus disease 2019 (COVID-19) patients.
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Epstein-Barr阳性病毒阳性2019年冠状病毒病（COVID-19）患者。
DOI：
10.1038/s41598-021-90351-y
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发表时间：
2021-05-25
影响因子：
4.6
通讯作者：
Chen C
中科院分区：
文献类型：
--
作者：
Chen T;Song J;Liu H;Zheng H;Chen C
本研究旨在检测2019冠状病毒病（COVID-19）中的EB病毒（EBV）合并感染。在这项回顾性单中心研究中，我们纳入了2020年1月9日至2月29日在武汉大学人民医院就诊的67名发病时间在2周内的COVID-19患者。根据EBV血清学检测结果将患者分为EBV/SARS-CoV-2合并感染组和SARS-CoV-2单独感染组，比较两组患者特征差异。中位年龄为37岁，其中35名（52.2%）为女性。在这些COVID-19患者中，37名（55.2%）患者的EBV病毒衣壳抗原（VCA）IgM抗体血清学阳性。EBV/SARS-CoV-2合并感染患者出现发热症状的风险是单纯SARS-CoV-2感染患者的3.09倍（95%CI 1.11-8.56; P = 0.03）。EBV/SARS-CoV-2合并感染组的C反应蛋白（CRP）（P = 0.02）和天门冬氨酸氨基转移酶（AST）（P = 0.04）高于单纯SARS-CoV-2感染组。EBV/SARS-CoV-2合并感染患者皮质类固醇使用比例高于SARS-CoV-2单独感染患者（P = 0.03）。我们发现COVID-19患者中EBV合并感染的发生率很高。EBV/SARS-CoV-2合并感染与发热和炎症增加相关。EBV再激活可能与COVID-19的严重程度相关。
The objective of this study was to detect the Epstein–Barr virus (EBV) coinfection in coronavirus disease 2019 (COVID-19). In this retrospective single-center study, we included 67 COVID-19 patients with onset time within 2 weeks in Renmin Hospital of Wuhan University from January 9 to February 29, 2020. Patients were divided into EBV/SARS-CoV-2 coinfection group and SARS-CoV-2 infection alone group according to the serological results of EBV, and the characteristics differences between the two groups were compared. The median age was 37 years, with 35 (52.2%) females. Among these COVID-19 patients, thirty-seven (55.2%) patients were seropositive for EBV viral capsid antigen (VCA) IgM antibody. EBV/SARS-CoV-2 coinfection patients had a 3.09-fold risk of having a fever symptom than SARS-CoV-2 infection alone patients (95% CI 1.11–8.56; P = 0.03). C-reactive protein (CRP) (P = 0.02) and the aspartate aminotransferase (AST) (P = 0.04) in EBV/SARS-CoV-2 coinfection patients were higher than that in SARS-CoV-2 infection alone patients. EBV/SARS-CoV-2 coinfection patients had a higher portion of corticosteroid use than the SARS-CoV-2 infection alone patients (P = 0.03). We find a high incidence of EBV coinfection in COVID-19 patients. EBV/SARS-CoV-2 coinfection was associated with fever and increased inflammation. EBV reactivation may associated with the severity of COVID-19.
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影响因子：
3.1
作者：
GLASER, R;KIECOLTGLASER, JK;HOLLIDAY, JE
通讯作者：
HOLLIDAY, JE
DOI：
10.1038/nrmicro.2016.81
发表时间：
2016-08
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
de Wit E;van Doremalen N;Falzarano D;Munster VJ
通讯作者：
Munster VJ
DOI：
10.1084/jem.185.9.1605
发表时间：
1997-05-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Steven NM;Annels NE;Kumar A;Leese AM;Kurilla MG;Rickinson AB
通讯作者：
Rickinson AB
DOI：
10.5501/wjv.v1.i1.31
发表时间：
2012-02-12
期刊：
World journal of virology
影响因子：
--
作者：
De Paschale, Massimo;Clerici, Pierangelo
通讯作者：
Clerici, Pierangelo
影响因子：
1.7
作者：
He, Hangyong;Wang, Yajing;Sun, Bing
通讯作者：
Sun, Bing