Optimum hypoglycemic therapy can improve coronary flow velocity reserve in diabetic patients: demonstration by transthoracic doppler echocardiography.
Optimum hypoglycemic therapy can improve coronary flow velocity reserve in diabetic patients: demonstration by transthoracic doppler echocardiography.
复制标题
最佳降血糖治疗可以改善糖尿病患者的冠状动脉血流速度储备：经胸多普勒超声心动图证实。
作者：
Chinami Miyazaki;M. Takeuchi;H. Yoshitani;S. Otani;K. Sakamoto;J. Yoshikawa
本研究的目的是通过经胸多普勒超声心动图（TTDE）确定消除或减轻高血糖是否会改善冠状动脉血流储备（CFVR）。应用TTDE测定49例糖尿病控制不良患者治疗前后左前降支CFVR，并与15例糖尿病控制良好患者进行对照。在强化治疗后20+/-15天，血糖控制不佳患者的空腹血糖水平从270 +/-106 mg/dl降至116+/-39 mg/dl。虽然基线冠状动脉血流速度（CFV）在两次测量之间没有变化（19.9+/-6.9 cm/s vs 19.0+/-5.4 cm/s，p=NS），但充血CFV在治疗后显著增加（47.3+/-13.4 cm/s vs 55.4+/-13.2 cm/s，p<0.001）。因此，治疗后CFVR显著改善（2.47+/-0.55 vs 2.98+/-0.56，p<0.001）。虽然对照组的改善很小（2.37+/-0.38 vs 2.50+/-0.37，p<0.05），但强化治疗控制不佳患者的CFVR改善明显大于对照组（0.51+/-0.33 vs 0.12+/-0.19，p<0.001）。这些结果表明，最佳的降糖治疗是重要的，以改善CFVR控制不佳的糖尿病患者。
The purpose of this study was to determine whether the elimination or the alleviation of hyperglycemia would improve coronary flow velocity reserve (CFVR) using transthoracic Doppler echocardiography (TTDE). CFVR was measured by TTDE in the left anterior descending coronary artery in 49 poorly controlled diabetic patients before and after antidiabetic treatment and 15 well controlled diabetic patients also underwent the same measurements. The fasting blood glucose level in the poorly controlled patients reduced from 270 +/-106 mg/dl to 116+/-39 mg/dl at 20+/-15 days after the intensive treatment. Although baseline coronary flow velocity (CFV) did not change between the 2 measurements (19.9+/-6.9 cm/s vs 19.0+/-5.4 cm/s, p=NS), the hyperemic CFV increased significantly after the treatment (47.3+/-13.4 cm/s vs 55.4+/-13.2 cm/s, p<0.001). Thus, the CFVR improved significantly after the treatment (2.47+/-0.55 vs 2.98+/-0.56, p<0.001). Although there was minimal improvement in the control group (2.37+/-0.38 vs 2.50+/-0.37, p<0.05), the improvement in CFVR was significantly greater in the poorly controlled patients with intensive treatment (0.51+/-0.33 vs 0.12+/-0.19, p<0.001) than that in the control group. These results suggest that optimal hypoglycemic therapy is important to improve the CFVR in poorly controlled diabetic patients.
影响因子：
--
作者：
BOHLEN, HG;LASH, JM
通讯作者：
LASH, JM
影响因子：
15.9
作者：
TESFAMARIAM, B;BROWN, ML;COHEN, RA
通讯作者：
COHEN, RA
影响因子：
37.8
作者：
Williams, SB;Goldfine, AB;Creager, MA
通讯作者：
Creager, MA