The SeroNet Clinical and Translational Serology Task Force (CTTF) SARS-CoV-2 mucosal immunity methodological considerations and best practices workshop.
The SeroNet Clinical and Translational Serology Task Force (CTTF) SARS-CoV-2 mucosal immunity methodological considerations and best practices workshop.
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DOI：
10.1080/21645515.2023.2253598
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发表时间：
2023-08-01
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
SARS-CoV-2在某些人群中仍然存在，即使接种了疫苗和增强剂。新出现的证据表明，减少病毒传播和感染可能需要参与粘膜免疫系统，特别是上呼吸道的分泌抗体。美国国家癌症研究所（NCI） COVID-19血清学科学网络（SeroNet）的临床和转化血清学工作组（CTTF）主办了一次研讨会，以审查粘膜样本采集方法和分析的发展和标准化状况，确定挑战，并制定行动计划以弥合差距。演讲者介绍了强调分泌性IgA在保护中的作用的数据，作为保护相关的粘膜标记物，跟踪和评估粘膜抗体的方法，以及从其他感染因子中吸取的教训。从监管机构和工业界的角度提出了指导粘膜疫苗开发的观点。强调了优化收集方案和分析以及协调数据的方法学考虑。严格的研究、标准化的方案、对照、标准和测定验证被认为是获得将SARS-CoV-2疫苗扩展到粘膜的势头的必要条件。
SARS-CoV-2 persists in certain populations, even with vaccination and boosters. Emerging evidence suggests that reductions in virus transmission and infection will likely require involvement of the mucosal immune system, especially secretory antibodies in the upper respiratory tract. The Clinical and Translational Serology Task Force (CTTF) within The National Cancer Institute (NCI)’s Serological Sciences Network for COVID-19 (SeroNet) hosted a workshop to review the status of development and standardization of mucosal sample collection methods and assays, identify challenges, and develop action plans to bridge gaps. Speakers presented data underscoring a role for secretory IgA in protection, mucosal markers as correlates of protection, methods for tracking and assessing mucosal antibodies, and lessons learned from other infectious agents. Perspectives from regulators and industry were put forward to guide mucosal vaccine development. Methodological considerations for optimizing collection protocols and assays and harmonizing data were highlighted. Rigorous studies, standardized protocols, controls, standards, and assay validation were identified as necessary to gain momentum in expanding SARS-CoV-2 vaccines to the mucosa.
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影响因子：
24.8
作者：
Isho B;Abe KT;Zuo M;Jamal AJ;Rathod B;Wang JH;Li Z;Chao G;Rojas OL;Bang YM;Pu A;Christie-Holmes N;Gervais C;Ceccarelli D;Samavarchi-Tehrani P;Guvenc F;Budylowski P;Li A;Paterson A;Yue FY;Marin LM;Caldwell L;Wrana JL;Colwill K;Sicheri F;Mubareka S;Gray-Owen SD;Drews SJ;Siqueira WL;Barrios-Rodiles M;Ostrowski M;Rini JM;Durocher Y;McGeer AJ;Gommerman JL;Gingras AC
通讯作者：
Gingras AC
影响因子：
15.9
作者：
Astronomo, Rena D.;Lemos, Maria P.;McElrath, M. Juliana
通讯作者：
McElrath, M. Juliana
DOI：
10.1126/science.aba9301
发表时间：
2020-10-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Habibi MS;Thwaites RS;Chang M;Jozwik A;Paras A;Kirsebom F;Varese A;Owen A;Cuthbertson L;James P;Tunstall T;Nickle D;Hansel TT;Moffatt MF;Johansson C;Chiu C;Openshaw PJM
通讯作者：
Openshaw PJM
影响因子：
11.1
作者：
Liew, Felicity;Talwar, Shubha;Cross, Andy;Willett, Brian J.;Scott, Sam;Logan, Nicola;Siggins, Matthew K.;Swieboda, Dawid;Sidhu, Jasmin K.;Efstathiou, Claudia;Moore, Shona C.;Davis, Chris;Mohamed, Noura;Nunag, Jose;King, Clara;Thompson, A. A. Roger;Rowland-Jones, Sarah L.;Docherty, Annemarie B.;Chalmers, James D.;Ho, Ling-Pei;Horsley, Alexander;Raman, Betty;Poinasamy, Krisnah;Marks, Michael;Kon, Onn Min;Howard, Luke;Wootton, Daniel G.;Dunachie, Susanna;Quint, Jennifer K.;Evans, Rachael A.;V. Wain, Louise;Fontanella, Sara;Silva, Thushan I. de;Ho, Antonia;Harrison, Ewen;Baillie, J. Kenneth;Semple, Malcolm G.;Brightling, Christopher;Thwaites, Ryan S.;Turtle, Lance;Openshaw, Peter J. M.
通讯作者：
Openshaw, Peter J. M.
影响因子：
24.8
作者：
Li, Conglei;Lam, Evelyn;Gommerman, Jennifer L.
通讯作者：
Gommerman, Jennifer L.