Intrinsically photosensitive retinal ganglion cells.
Intrinsically photosensitive retinal ganglion cells.
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DOI：
10.1152/physrev.00013.2010
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发表时间：
2010-10
影响因子：
33.6
通讯作者：
Yau KW
中科院分区：
文献类型：
--
作者：
Do MT;Yau KW
地球上的生命受制于地球自转造成的昼夜交替。因此，生物已经进化出光电探测系统，使其生理和行为与外部光暗周期同步。这种形式的光电探测与人们熟悉的“图像视觉”不同，因为基本信息是随时间变化的亮或暗，与空间模式无关。“非图像”视觉可能比图像视觉更古老，并且在生物物种中广泛存在。对于哺乳动物来说，长期以来一直认为非图像视觉的光感受器也是教科书上的视杆细胞和视锥细胞。然而，近年来，在哺乳动物眼睛中发现了一小群视网膜神经节细胞，它们表达一种称为黑视素的独特视觉色素。这些神经节细胞具有固有的感光性，并驱动各种非图像视觉功能。除了本身是光感受器之外，它们还构成了将视杆细胞和视锥细胞信号传递到大脑的主要通道，用于非图像视觉功能，例如昼夜光诱导和瞳孔光反射。在这里，我们回顾什么是已知的这些新的哺乳动物光感受器。
Life on earth is subject to alternating cycles of day and night imposed by the rotation of the earth. Consequently, living things have evolved photodetective systems to synchronize their physiology and behavior with the external light-dark cycle. This form of photodetection is unlike the familiar “image vision,” in that the basic information is light or darkness over time, independent of spatial patterns. “Nonimage” vision is probably far more ancient than image vision and is widespread in living species. For mammals, it has long been assumed that the photoreceptors for nonimage vision are also the textbook rods and cones. However, recent years have witnessed the discovery of a small population of retinal ganglion cells in the mammalian eye that express a unique visual pigment called melanopsin. These ganglion cells are intrinsically photosensitive and drive a variety of nonimage visual functions. In addition to being photoreceptors themselves, they also constitute the major conduit for rod and cone signals to the brain for nonimage visual functions such as circadian photoentrainment and the pupillary light reflex. Here we review what is known about these novel mammalian photoreceptors.
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影响因子：
2.9
作者：
CAHILL, GM;MENAKER, M
通讯作者：
MENAKER, M
DOI：
10.1111/j.1460-9568.2009.06631.x
发表时间：
2009-02
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Cameron MA;Pozdeyev N;Vugler AA;Cooper H;Iuvone PM;Lucas RJ
通讯作者：
Lucas RJ
DOI：
10.1073/pnas.250478897
发表时间：
2000-12-05
影响因子：
11.1
作者：
Calvert, PD;Krasnoperova, NV;Lem, J
通讯作者：
Lem, J
影响因子：
1.9
作者：
Barnard, AR;Appleford, JM;Lucas, RJ
通讯作者：
Lucas, RJ
影响因子：
9.8
作者：
Bellingham, James;Chaurasia, Shyam S.;Lucas, Robert J.
通讯作者：
Lucas, Robert J.