Nicotelline: a proposed biomarker and environmental tracer for particulate matter derived from tobacco smoke.
Nicotelline: a proposed biomarker and environmental tracer for particulate matter derived from tobacco smoke.
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DOI：
10.1021/tx400094y
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发表时间：
2013-11-18
影响因子：
4.1
通讯作者：
Benowitz NL
中科院分区：
文献类型：
--
作者：
Jacob P 3rd;Goniewicz ML;Havel CM;Schick SF;Benowitz NL
来自烟草烟雾的颗粒物（PM）含有许多有毒物质。由于烟草烟雾的PM和气相在环境中可能分布不同，并且其中的物质可能具有不同的人体生物利用度，因此需要烟草烟雾成分的多种示踪剂和生物标志物。尼古丁是烟草烟雾中相对不挥发的生物碱，因此它有可能成为烟草烟雾来源的PM的合适示踪剂和生物标志物。我们描述的实验表明，尼古丁几乎完全存在于PM中，在新鲜产生的香烟烟雾和老年香烟烟雾。尼古丁的质量和质量之间的一个很好的相关性，在老化的香烟smoke.We还描述了实验表明，烟草烟雾中尼古丁的主要来源是另一个很少研究的烟草生物碱，anatalline，在燃烧过程中脱氢。我们发现，尼古丁代谢产物可以在吸烟者的尿液中测量，尼古丁可以在吸烟者和非吸烟者家中的灰尘中测量。我们的结论是，尼古丁应该是有用的示踪剂和生物标志物PM来自烟草烟雾。
Particulate matter (PM) derived from tobacco smoke contains numerous toxic substances. Since the PM and gas phase of tobacco smoke may distribute differently in the environment, and substances in them may have different human bioavailability, multiple tracers and biomarkers for tobacco smoke constituents are desirable. Nicotelline is a relatively non-volatile alkaloid present in tobacco smoke, and therefore it has the potential to be a suitable tracer and biomarker for tobacco smoke-derived PM. We describe experiments demonstrating that nicotelline is present almost entirely in the PM, in both freshly generated cigarette smoke and aged cigarette smoke. An excellent correlation between the mass of nicotelline and the mass of the PM in aged cigarette smoke was found. We also describe experiments suggesting that the main source of nicotelline in tobacco smoke is dehydrogenation of another little-studied tobacco alkaloid, anatalline, during the burning process. We show that nicotelline metabolites can be measured in urine of smokers, and that nicotelline can be measured in house dust from homes of smokers and non-smokers. We conclude that nicotelline should be useful as a tracer and biomarker for PM derived from tobacco smoke.
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DOI：
10.1158/1055-9965.epi-09-0874
发表时间：
2009-12
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Goniewicz ML;Havel CM;Peng MW;Jacob P 3rd;Dempsey D;Yu L;Zielinska-Danch W;Koszowski B;Czogala J;Sobczak A;Benowitz NL
通讯作者：
Benowitz NL
影响因子：
2.7
作者：
Hang, Bo;Sarker, Altaf H.;Gundel, Lara A.
通讯作者：
Gundel, Lara A.
影响因子：
11.4
作者：
BENNER, CL;BAYONA, JM;EATOUGH, DJ
通讯作者：
EATOUGH, DJ
影响因子：
15
作者：
Englert, SME;McElvain, SM
通讯作者：
McElvain, SM
影响因子：
4.5
作者：
BINNS, R;BEVEN, JL;LUGTON, WGD
通讯作者：
LUGTON, WGD