Operating on chromatin, a colorful language where context matters.
Operating on chromatin, a colorful language where context matters.
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DOI：
10.1016/j.jmb.2011.01.040
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发表时间：
2011-05-27
影响因子：
5.6
通讯作者：
Strahl BD
中科院分区：
文献类型：
--
作者：
Gardner KE;Allis CD;Strahl BD
组蛋白是真核 DNA 的基本包装元件，经过多种翻译后修饰 (PTM) 的高度修饰，这些修饰被认为可以控制染色质的结构和功能。十年前，我们提出了组蛋白密码假说，该假说提供了一个模型来解释组蛋白上的单个和/或组合 PTM 如何调节与染色质相关的多种活动（例如基因转录）。当时，人们对组蛋白上发生的 PTM 数量以及放置、移除和解释它们的蛋白质的了解有限。自从这一假说的概念提出以来，该领域见证了我们对有助于组蛋白 PTM 建立的酶以及结合它们的多种效应蛋白的理解取得了前所未有的进步。虽然关于组蛋白 PTM 是否真正构成严格“代码”的争论仍在继续，但越来越清楚的是，组蛋白上的 PTM 以精心组合的方式发挥作用，以调节与染色质相关的许多活动。在本期特刊中，我们通过一篇综述来庆祝具有里程碑意义的 lac 操纵子发表 50 周年，该综述提供了对组蛋白密码假说的当前看法、我们在过去十年中吸取的经验教训以及将推动我们未来对组蛋白 PTM 理解向前发展的技术。
Histones, the fundamental packaging elements of eukaryotic DNA, are highly decorated with a diverse set of post-translational modifications (PTMs) that are recognized to govern the structure and function of chromatin. Ten years ago, we put forward the histone code hypothesis, which provided a model to explain how single and/or combinatorial PTMs on histones regulate the diverse activities associated with chromatin (e.g. gene transcription). At that time, there was a limited understanding of both the number of PTMs that occur on histones as well as the proteins that place, remove and interpret them. Since the conception of this hypothesis, the field has witnessed an unprecedented advance in our understanding of the enzymes that contribute to the establishment of histone PTMs, as well as the diverse effector proteins that bind them. While debate continues as to whether histone PTMs truly constitute a strict “code”, it is becoming clear that PTMs on histone proteins function in elaborate combinations to regulate the many activities associated with chromatin. In this special issue, we celebrate the 50th anniversary of the landmark publication of the lac operon with a review that provides a current view of the histone code hypothesis, the lessons we have learned over the last decade, and the technologies that will drive our understanding of histone PTMs forward in the future.
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影响因子：
56.9
作者：
Huang, Y;Fang, J;Xu, RM
通讯作者：
Xu, RM
染色质结合模块的组合分析揭示了多位点歧视。
影响因子：
14.8
作者：
Garske, Adam L.;Oliver, Samuel S.;Wagner, Elise K.;Musselman, Catherine A.;LeRoy, Gary;Garcia, Benjamin A.;Kutateladze, Tatiana G.;Denu, John M.
通讯作者：
Denu, John M.
DOI：
10.1073/pnas.51.5.786
发表时间：
1964-01-01
影响因子：
11.1
作者：
ALLFREY, VG;FAULKNER, R;MIRSKY, AE
通讯作者：
MIRSKY, AE
影响因子：
16.8
作者：
Collins, Robert E.;Northrop, Jeffrey P.;Cheng, Xiaodong
通讯作者：
Cheng, Xiaodong
影响因子：
9.2
作者：
Fuchs, Stephen M.;Krajewski, Krzysztof;Baker, Richard W.;Miller, Victoria L.;Strahl, Brian D.
通讯作者：
Strahl, Brian D.