Contribution of white matter hyperintensities to ventricular enlargement in older adults.
Contribution of white matter hyperintensities to ventricular enlargement in older adults.
复制标题
白质高信号对老年人心室扩大的影响。
DOI：
10.1016/j.nicl.2022.103019
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发表时间：
2022
影响因子：
4.2
通讯作者：
Wardlaw, Joanna M.
中科院分区：
文献类型：
--
作者：
Jochems, Angela C. C.;Maniega, Susana Munoz;Hernandez, Maria del C. Valdes;Barclay, Gayle;Anblagan, Devasuda;Ballerini, Lucia;Meijboom, Rozanna;Wiseman, Stewart;Taylor, Adele M.;Corley, Janie;Chappell, Francesca M.;V. Backhouse, Ellen;Stringer, Michael S.;Dickie, David Alexander;Bastin, Mark E.;Deary, Ian J.;Cox, Simon R.;Wardlaw, Joanna M.
关键词：
已知侧脑室的体积随着年龄的增长而增加。WMH通常存在于老年人的大脑中。我们研究了WMH和侧脑室容积变化之间的关系。WMH在约20%的病例中消退，但心室在6年内稳定增加。独立于萎缩和其他危险因素，WMH有助于心室生长。由于与脑萎缩相关的广泛组织损失，侧脑室可能会增加。或者，它们可能扩展到与白色高信号（WMH）相关的组织缺损区域。我们在1936年洛锡安出生队列的参与者中评估了侧脑室和WMH体积之间的纵向关联，包括73岁，76岁和79岁时的总脑体积，血压，中风史，心血管疾病，糖尿病和吸烟，包括所有可用时间点的MRI数据。侧脑室容积随年龄增长而逐渐增大，WMH容积变化较大。WMH体积减少20%，其余受试者增加。6年后，侧脑室体积每增加3%，血压每增加0.1%，总脑体积每减少1%，WMH体积每增加1%，侧脑室体积增加3.2%，WMH体积增加4.5%。随着时间的推移，女性的侧脑室体积比男性小19%。心室和WMH体积变化与一般脑萎缩适度相关且独立，表明其潜在过程并不完全重叠。
Lateral ventricles are known to increase in volume with age. WMH are commonly found in the older brain. We examined associations between WMH and lateral ventricle volume changes. WMH regress in around 20% of cases, but ventricles increased steadily over 6 years. Independently of atrophy and other risk factors, WMH contribute to ventricle growth. Lateral ventricles might increase due to generalized tissue loss related to brain atrophy. Alternatively, they may expand into areas of tissue loss related to white matter hyperintensities (WMH). We assessed longitudinal associations between lateral ventricle and WMH volumes, accounting for total brain volume, blood pressure, history of stroke, cardiovascular disease, diabetes and smoking at ages 73, 76 and 79, in participants from the Lothian Birth Cohort 1936, including MRI data from all available time points. Lateral ventricle volume increased steadily with age, WMH volume change was more variable. WMH volume decreased in 20% and increased in remaining subjects. Over 6 years, lateral ventricle volume increased by 3% per year of age, 0.1% per mm Hg increase in blood pressure, 3.2% per 1% decrease of total brain volume, and 4.5% per 1% increase of WMH volume. Over time, lateral ventricle volumes were 19% smaller in women than men. Ventricular and WMH volume changes are modestly associated and independent of general brain atrophy, suggesting that their underlying processes do not fully overlap.
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DOI：
10.1136/bmj.c3666
发表时间：
2010-07-26
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Debette S;Markus HS
通讯作者：
Markus HS
影响因子：
4.1
作者：
Deary IJ;Gow AJ;Taylor MD;Corley J;Brett C;Wilson V;Campbell H;Whalley LJ;Visscher PM;Porteous DJ;Starr JM
通讯作者：
Starr JM
影响因子：
5.7
作者：
Bastin, Mark E.;Maniega, Susana Munoz;Clayden, Jonathan D.
通讯作者：
Clayden, Jonathan D.
影响因子：
5.7
作者：
Hernandez, Maria del C. Valdes;Morris, Zoe;Wardlaw, Joanna M.
通讯作者：
Wardlaw, Joanna M.
影响因子：
9.9
作者：
Alperin, Noam;Oliu, Carlos J.;Relkin, Norman
通讯作者：
Relkin, Norman