Exploration of NIR Squaraine Contrast Agents Containing Various Heterocycles: Synthesis, Optical Properties and Applications.
Exploration of NIR Squaraine Contrast Agents Containing Various Heterocycles: Synthesis, Optical Properties and Applications.
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DOI：
10.3390/ph16091299
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发表时间：
2023-09-14
期刊：
影响因子：
--
通讯作者：
Henary M
中科院分区：
文献类型：
--
作者：
Sarasiya S;Sarasiya S;Henary M
方酸染料是一类流行的对比近红外（NIR）染料。方酸菁染料已经显示出用各种杂环修饰的能力。吲哚部分是方酸菁染料中最值得注意的杂环。大量的工作已经投入到开发吲哚基方酸菁染料和确定其应用。含有吲哚部分的方酸菁染料的光学性质促进高量子产率和摩尔吸光系数，但吸收最大值在700 nm附近封顶。这是吲哚基方酸菁染料的主要限制。相比之下，其他具有较大共轭体系的杂环化合物，如喹啉和perimidine，已经证明了有前途的光学性质和巨大的修饰潜力，尽管发展有限。喹啉和萘啶类方酸染料的摩尔消光系数超过100，000 M−1 cm−1，消光系数超过800 nm。本报告将着眼于吲哚，喹啉，并perimidine为基础的方酸染料。由于报告的染料数量庞大，对吲哚基方酸菁染料的搜索仅限于过去五年（2018-2023）的报告。由于上述限制，对喹啉和萘啶类方酸菁染料进行了整体搜索，以分析其光学性质和应用。本报告将评估三种不同类别的方酸菁：吲哚，喹啉，并基于perimidine，以评估其光学性质和应用，鼓励探索其他杂环用于方酸菁染料的目标。
Squaraine dye is a popular class of contrast near-infrared (NIR) dyes. Squaraine dyes have shown the ability to be modified with various heterocycles. The indole moiety is the most notable heterocycle incorporated in squaraine dyes. A tremendous amount of work has gone into developing indole-based squaraine dyes and determining their applications. The optical properties of squaraine dyes containing an indole moiety facilitate high quantum yields and molar absorptivity, but the absorbance maxima is capped near 700 nm. This is the major limitation of indole-based squaraine dyes. In comparison, other heterocycles with larger conjugated systems such as quinoline and perimidine have demonstrated promising optical properties and immense potential for modifications, albeit with limited development. Quinoline- and perimidine-based squaraine dyes have molar extinction coefficients over 100,000 M−1 cm−1 and absorbances over 800 nm. This report will look at indole-, quinoline-, and perimidine-based squaraine dyes. Due to the sheer number of reported dyes, the search for indole-based squaraine dyes has been limited to reports from the past five years (2018–2023). For quinoline- and perimidine-based squaraine dyes, a holistic search was performed to analyze the optical properties and applications, due to the abovementioned limitation. This report will evaluate the three different classes of squaraines: indole-, quinoline-, and perimidine-based, to evaluate their optical properties and applications, with the goal of encouraging the exploration of other heterocycles for use in squaraine dyes.
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