The Extracellular Matrix and Vesicles Modulate the Breast Tumor Microenvironment.
The Extracellular Matrix and Vesicles Modulate the Breast Tumor Microenvironment.
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DOI：
10.3390/bioengineering7040124
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发表时间：
2020-10-11
期刊：
影响因子：
--
通讯作者：
Zorlutuna P
中科院分区：
文献类型：
--
作者：
Yang J;Bahcecioglu G;Zorlutuna P
新出现的证据表明，肿瘤微环境（TME）成分，特别是细胞外基质（ECM），在乳腺癌的发展，进展和转移的多种作用。除了乳腺ECM的生物物理性质和生化组成外，信号分子在维持体内平衡方面极其重要，并且在乳腺TME中，它们作为促进肿瘤进展和免疫逃避的关键组分。细胞外囊泡（EV）是通过信号分子在细胞及其微环境之间传递信息的介质，刚刚开始在乳腺癌研究中引起关注。在这篇全面的综述中，我们首先概述了ECM在乳腺癌进展中的影响以及在此过程中TME发生的变化。还讨论了EV及其生物分子含量在乳腺癌进展和转移中的重要性。最后，我们讨论了这些细胞外成分的潜在生物医学或临床应用，以及它们如何影响治疗结果。
Emerging evidence has shown multiple roles of the tumor microenvironment (TME) components, specifically the extracellular matrix (ECM), in breast cancer development, progression, and metastasis. Aside from the biophysical properties and biochemical composition of the breast ECM, the signaling molecules are extremely important in maintaining homeostasis, and in the breast TME, they serve as the key components that facilitate tumor progression and immune evasion. Extracellular vesicles (EVs), the mediators that convey messages between the cells and their microenvironment through signaling molecules, have just started to capture attention in breast cancer research. In this comprehensive review, we first provide an overview of the impact of ECM in breast cancer progression as well as the alterations occurring in the TME during this process. The critical importance of EVs and their biomolecular contents in breast cancer progression and metastasis are also discussed. Finally, we discuss the potential biomedical or clinical applications of these extracellular components, as well as how they impact treatment outcomes.
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影响因子：
4.6
作者：
Cavo M;Fato M;Peñuela L;Beltrame F;Raiteri R;Scaglione S
通讯作者：
Scaglione S
影响因子：
50.3
作者：
Allinen, M;Beroukhim, R;Polyak, K
通讯作者：
Polyak, K
影响因子：
7.8
作者：
David JM;Dominguez C;Hamilton DH;Palena C
通讯作者：
Palena C
DOI：
10.1158/1055-9965.epi-17-0720
发表时间：
2018-03
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Conklin MW;Gangnon RE;Sprague BL;Van Gemert L;Hampton JM;Eliceiri KW;Bredfeldt JS;Liu Y;Surachaicharn N;Newcomb PA;Friedl A;Keely PJ;Trentham-Dietz A
通讯作者：
Trentham-Dietz A
影响因子：
3.7
作者：
Boyd NF;Li Q;Melnichouk O;Huszti E;Martin LJ;Gunasekara A;Mawdsley G;Yaffe MJ;Minkin S
通讯作者：
Minkin S