Evidence that breast tissue stiffness is associated with risk of breast cancer.
Evidence that breast tissue stiffness is associated with risk of breast cancer.
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DOI：
10.1371/journal.pone.0100937
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Minkin S
中科院分区：
文献类型：
--
作者：
Boyd NF;Li Q;Melnichouk O;Huszti E;Martin LJ;Gunasekara A;Mawdsley G;Yaffe MJ;Minkin S
来自动物模型的证据表明，组织僵硬会增加癌症的侵袭和进展，包括乳腺癌。在这里，我们使用在乳房X光摄影过程中测量压缩的乳房的体积和投影面积来估计乳房组织硬度，并检查僵硬与乳腺癌风险的关系。用乳房X光片测量了362例新诊断乳腺癌患者(病例)和656例同龄非乳腺癌患者(对照组)未受影响的乳腺组织的总体积和放射密度。测量乳房组织体积和在乳房X光摄影过程中压缩乳房的投影面积，以计算在压缩过程中乳房的变形，并利用记录的压缩力来估计乳房组织的硬度。在病例和对照中比较僵硬，并在调整其他危险因素后检查与乳腺癌风险的相关性。在通过面积测量和其他风险因素调整了乳房X光检查密度百分比后，我们对乳房组织硬度的估计与乳腺癌显著相关(优势比 = 1.21，95%可信区间 = 1.03，1.43，p = 0.02)，并通过面积和体积测量改善了乳房X光检查密度百分比模型中乳腺癌风险的预测。乳房组织硬度的估计与乳腺癌风险相关，并基于乳房X光检查测量和其他风险因素改进风险预测。僵硬可能提供了一种额外的机制，通过这种机制，乳房组织的组成与乳腺癌的风险有关，值得使用更直接的测量方法进行检查。
Evidence from animal models shows that tissue stiffness increases the invasion and progression of cancers, including mammary cancer. We here use measurements of the volume and the projected area of the compressed breast during mammography to derive estimates of breast tissue stiffness and examine the relationship of stiffness to risk of breast cancer. Mammograms were used to measure the volume and projected areas of total and radiologically dense breast tissue in the unaffected breasts of 362 women with newly diagnosed breast cancer (cases) and 656 women of the same age who did not have breast cancer (controls). Measures of breast tissue volume and the projected area of the compressed breast during mammography were used to calculate the deformation of the breast during compression and, with the recorded compression force, to estimate the stiffness of breast tissue. Stiffness was compared in cases and controls, and associations with breast cancer risk examined after adjustment for other risk factors. After adjustment for percent mammographic density by area measurements, and other risk factors, our estimate of breast tissue stiffness was significantly associated with breast cancer (odds ratio = 1.21, 95% confidence interval = 1.03, 1.43, p = 0.02) and improved breast cancer risk prediction in models with percent mammographic density, by both area and volume measurements. An estimate of breast tissue stiffness was associated with breast cancer risk and improved risk prediction based on mammographic measures and other risk factors. Stiffness may provide an additional mechanism by which breast tissue composition is associated with risk of breast cancer and merits examination using more direct methods of measurement.
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影响因子：
3.8
作者：
Yaffe, M. J.;Boone, J. M.;Brock, K.
通讯作者：
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影响因子：
3.8
作者：
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通讯作者：
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DOI：
10.1083/jcb.201102147
发表时间：
2012-02-20
期刊：
The Journal of cell biology
影响因子：
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作者：
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通讯作者：
Werb Z
影响因子：
3.8
作者：
Li, T;Sun, LM;Boyd, N
通讯作者：
Boyd, N
DOI：
10.1016/j.biocel.2007.06.025
发表时间：
2007-01-01
影响因子：
4
作者：
Kass, Laura;Erler, Janine T.;Weaver, Valerie M.
通讯作者：
Weaver, Valerie M.