Pneumococcal carriage in young children one year after introduction of the 13-valent conjugate vaccine in Italy.
Pneumococcal carriage in young children one year after introduction of the 13-valent conjugate vaccine in Italy.
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DOI：
10.1371/journal.pone.0076309
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Pantosti A
中科院分区：
文献类型：
--
作者：
Camilli R;Daprai L;Cavrini F;Lombardo D;D'Ambrosio F;Del Grosso M;Vescio MF;Landini MP;Pascucci MG;Torresani E;Garlaschi ML;Sambri V;Pantosti A
2010年年中，意大利的儿童免疫接种中，7价肺炎球菌结合疫苗（PCV 7）被13价结合疫苗（PCV 13）取代。我们在这项研究中的目的是获得一个快照的肺炎球菌携带频率，定殖血清型和抗生素耐药性在两个意大利城市的健康儿童在一年后，PCV 13的介绍。从2011年11月至2012年4月期间，从571名0-5岁儿童中获得鼻咽拭子。肺炎球菌分离株进行血清分型和抗菌药物敏感性测试。采用多位点序列分型（MLST）分析青霉素和/或红霉素非敏感分离株。在接受检查的儿童中，81.2%接受过至少一剂PCV 7或PCV 13，74.9%完成了针对其年龄的推荐疫苗接种计划。在后者中，57.3%的儿童接种了PCV 7，27.1%接种了PCV 13，15.6%接种了两种疫苗的组合。总体携带率为32.9%，6-35个月的儿童最容易发生肺炎球菌定植（6-23个月OR：3.75; 95%CI：2.19-6.43和24-35个月OR：3.15，95%CI：2.36-4.22）。共对184株肺炎球菌进行了血清分型，分为PCV 7（5.4%）、PCV 13（18.0%）和非PCV 13（82.0%）血清型。血清型6C、24 F和19 A是最普遍的（分别为10.3%、8.6%和8.1%）。青霉素不敏感（MIC > 0.6mg/L）占30.9%，红霉素耐药占42.3%。非PCV 13血清型分别占青霉素和红霉素非敏感分离株的75.4%和70.8%。我们的研究结果显示，意大利儿童中PCV 7和PCV 13血清型的发生率较低，可能是由于疫苗接种的影响。随着PCV 13的继续使用，将评估其对疫苗血清型（如19 A）和交叉反应血清型（如6C）的潜在影响，本研究为进一步分析监测分离株提供了基线。
In mid 2010, the 7-valent pneumococcal conjugate vaccine (PCV7) was replaced by the 13-valent conjugate vaccine (PCV13) for childhood immunization in Italy. Our objective in this study was to obtain a snapshot of pneumococcal carriage frequency, colonizing serotypes, and antibiotic resistance in healthy children in two Italian cities one year after PCV13 was introduced. Nasopharyngeal swabs were obtained from 571 children aged 0-5 years from November 2011-April 2012. Pneumococcal isolates were serotyped and tested for antimicrobial susceptibility. Penicillin and/or erythromycin non-susceptible isolates were analyzed by Multi Locus Sequence Typing (MLST). Among the children examined, 81.2% had received at least one dose of PCV7 or PCV13 and 74.9% had completed the recommended vaccination schedule for their age. Among the latter, 57.3% of children had received PCV7, 27.1% PCV13, and 15.6% a combination of the two vaccines. The overall carriage rate was 32.9%, with children aged 6-35 months the most prone to pneumococcal colonization (6-23 months OR: 3.75; 95% CI: 2.19-6.43 and 24-35 months OR: 3.15, 95%CI: 2.36-4.22). A total of 184 pneumococcal isolates were serotyped and divided into PCV7 (5.4%), PCV13 (18.0%), and non-PCV13 (82.0%) serotypes. Serotypes 6C, 24F, and 19A were the most prevalent (10.3%, 8.6%, and 8.1%, respectively). The proportion of penicillin non-susceptible (MIC >0.6 mg/L) isolates was 30.9%, while 42.3% were erythromycin resistant. Non-PCV13 serotypes accounted for 75.4% and 70.8% of the penicillin and erythromycin non-susceptible isolates, respectively. Our results revealed low rates of PCV7 and PCV13 serotypes in Italian children, potentially due to the effects of vaccination. As the use of PCV13 continues, its potential impact on vaccine serotypes such as 19A and cross-reactive serotypes such as 6C will be assessed, with this study providing a baseline for further analysis of surveillance isolates.
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6.4
作者：
Beall, Bernard W.;Gertz, Robert E.;Brueggemann, Angela B.
通讯作者：
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影响因子：
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作者：
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作者：
Cardozo, Dea M.;Nascimento-Carvalho, Cristiana M.;Brandileone, Maria-Cristina C.
通讯作者：
Brandileone, Maria-Cristina C.
DOI：
10.1007/s10096-011-1154-9
发表时间：
2011-07-01
影响因子：
4.5
作者：
Dunais, B.;Bruno-Bazureault, P.;Pradier, C.
通讯作者：
Pradier, C.