Reduced serotonergic immunoreactive fibers in the forebrain of alcohol-preferring rats.
Reduced serotonergic immunoreactive fibers in the forebrain of alcohol-preferring rats.
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嗜酒大鼠前脑中的血清素免疫反应纤维减少。
DOI：
10.1111/j.1530-0277.1994.tb00912.x
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Li,TK
中科院分区：
文献类型：
--
作者：
Zhou,FC;Bledsoe,S;Lumeng,L;Li,TK
我们之前的研究表明，与不偏好酒精的大鼠 (NP) 相比，偏好酒精的大鼠 (P) 大脑特定区域的 5-羟色胺 (5-HT) 免疫反应纤维密度降低。我们目前的研究结果表明，P 大鼠前脑其他选定区域的 5-HT 神经支配存在定量和定性差异。通过免疫细胞化学和定量图像分析测量年轻成年 P 和 NP 大鼠大脑中的 5-HT 纤维密度。解决了神经纤维二维定量的常规误差并进行了调整。与 NP 大鼠相比，背侧海马、尾壳核和下丘脑的 CA4 和灰筋膜中 5-HT 纤维的数量显着降低（未配对的 Student t 检验）。在检查纤维类型时，我们发现，在额叶皮质和海马区域，通常具有小静脉曲张的细 5-HT 纤维和具有大静脉曲张的粗 5-HT 纤维与 NP 大鼠相比，P 大鼠中观察到的细 5-HT 纤维较少，已知细纤维容易受到滥用药物的影响。这些观察结果表明，(a) 5-HT 神经支配存在数量差异，或者某些 5-HT 纤维中的 5-HT 降低至免疫细胞化学无法检测到的水平，(b) 与 NP 大鼠相比，P 大鼠选定的大脑区域中的细 5-HT 纤维明显减少到更大程度。讨论了 5-HT 系统与酒精滥用的关系。
Our previous study indicated that 5‐hydroxytryptamine (5‐HT) immunoreactive fiber densities were decreased in specific areas of the brain in alcohol‐preferring rats (P) when compared with alcohol‐nonpreferring rats (NP). The results of our current study show that there are quantitative and qualitative differences in 5‐HT innervation in other selected regions of the forebrains of P rats. The 5‐HT fiber density in the brains of young adult P and NP rats was measured by immunocytochemistry and quantitative image analysis. A routine error of two‐dimensional quantitation of nerve fiber was addressed and an adjustment was made. The amount of 5‐HT fibers was significantly lower in CA4 and fasciola cinereum of the dorsal hippocampus, caudate‐putamen, and hypothalamus of the P as compared with NP rats (unpaired Student's t tests).In examining the fiber types, we found that, in the frontal cortical and hippocampal regions, where normally fine 5‐HT fibers with small varicosities and thick 5‐HT fibers with large varicosities coexist, fewer fine 5‐HT fibers were seen in P rats as compared with NP rats the fine fibers are known to be vulnerable to abusive drugs. These observations indicate that (a) there are quantitative differences in 5‐HT innervation or that the 5‐HT in some 5‐HT fibers is reduced to a level undetectable by immunocytochemistry, and (b) the fine 5‐HT fibers are specifically reduced to a greater degree in the selected brain regions of P rats when compared with that of NP rats. The involvement of the 5‐HT system in the alcohol abuse is discussed.
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诱导海马中血清素能纤维的同型发芽。
影响因子：
2.9
作者：
F. Zhou;E. Azmitia
通讯作者：
E. Azmitia
诱导大鼠海马血清素能纤维同型侧枝出芽
影响因子：
2.9
作者：
F. Zhou;E. Azmitia
通讯作者：
E. Azmitia
血清素神经元的神经营养因子可防止小脑中移植的中缝神经元的变性
影响因子：
2.9
作者：
F. Zhou;E. Azmitia
通讯作者：
E. Azmitia
影响因子：
2.3
作者：
MCBRIDE, WJ;MURPHY, JM;LI, TK
通讯作者：
LI, TK
血清素和乙醇偏好。
DOI：
--
发表时间：
1989
期刊：
Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism
影响因子：
--
作者：
W. Mcbride;J. Murphy;L. Lumeng;T. Li
通讯作者：
T. Li