Low awareness of oral and injectable PrEP among high-risk adolescent girls and young women in Kampala, Uganda.
Low awareness of oral and injectable PrEP among high-risk adolescent girls and young women in Kampala, Uganda.
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DOI：
10.1186/s12879-022-07398-z
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发表时间：
2022-05-16
影响因子：
3.7
通讯作者：
Mayanja, Yunia
中科院分区：
文献类型：
--
作者：
Lunkuse, Jane Frances;Kamacooko, Onesmus;Muturi-Kioi, Vincent;Chinyenze, Kundai;Kuteesa, Monica O.;Price, Matt A.;Mayanja, Yunia
少女和青年妇女在全世界新感染艾滋病毒的人数中所占比例过高。乌干达年轻性工作者的艾滋病毒感染率为22.5%。虽然接触前预防（PrEP）是一种非常有效的生物医学艾滋病毒预防方法，但乌干达青年工作者对PrEP的认识尚未得到系统研究。我们的目的是评估对PrEP的认识以及与经常报告有偿性行为的AGYW对PrEP的认识相关的因素。我们于2019年1月至10月在乌干达坎帕拉的14-24岁艾滋病毒感染高危人群中进行了一项横断面研究。参与者使用国家筛选工具筛选PrEP资格，其中82.3%有资格。通过访谈收集了有关社会人口统计学、行为和性风险的数据。对口服或注射PrEP的认识，后者目前处于后期试验阶段，被定义为一个人是否听说过PrEP作为艾滋病毒预防方法。使用多变量稳健泊松回归模型评估与口服PrEP意识相关的因素。我们招募了285名参与者，其中39.3%在20岁以下，54.7%完成了中学教育，68.8%在过去3个月内有多个性伴侣，8.8%被筛选为高危饮酒者/酒精依赖者（AUDIT工具），21.0%报告性工作为主要职业。只有23.2%的人知道口服PrEP，3.9%的人听说过注射PrEP。（aPR 1.89，95% CI 1.08-3.29）和有多个性伴侣者（aPR 1.84，95%CI 1.01-3.35），但在与最近性伴侣持续使用安全套的人群中较低（aPR 0.58，95%CI 0.37-0.91）。大多数AGYW不知道任何形式的PrEP。那些有较高风险的行为，即酒精依赖者或多个性伴侣，更了解口服PrEP。需要采取干预措施，提高女性青年的认识。提高PrEP意识对于提高乌干达高风险AGYW中PrEP的吸收至关重要。
Adolescent girls and young women (AGYW) account for a disproportionate number of new HIV infections worldwide. HIV prevalence among young sex workers in Uganda is 22.5%. Although pre-exposure prophylaxis (PrEP) is a highly effective biomedical HIV prevention method, awareness of PrEP among AGYW in Uganda has not been studied systematically. We aimed to assess awareness of PrEP and factors associated with awareness of PrEP among AGYW who frequently reported paid sex. We conducted a cross-sectional study among 14–24-year old AGYW at high risk of HIV infection in Kampala, Uganda from January to October 2019. Participants were screened for PrEP eligibility using a national screening tool of whom 82.3% were eligible. Data on socio-demographics, behavioral and sexual risks were collected by interview. Awareness of oral or injectable PrEP, the latter of which is currently in late-stage trials, was defined as whether an individual had heard about PrEP as an HIV prevention method. Multivariable robust poisson regression model was used to assess factors associated with oral PrEP awareness. We enrolled 285 participants of whom 39.3% were under 20 years old, 54.7% had completed secondary education, 68.8% had multiple sex partners in the past 3 months, 8.8% were screened as high risk drinkers’/ alcohol dependent (AUDIT tool) and 21.0% reported sex work as main occupation. Only 23.2% were aware of oral PrEP and 3.9% had heard about injectable PrEP. The prevalence of oral PrEP awareness was significantly higher among volunteers screened as alcohol dependents (aPR 1.89, 95% CI 1.08–3.29) and those with multiple sexual partners (aPR 1.84, 95% CI 1.01–3.35), but was lower among those who reported consistent condom use with recent sexual partners (aPR 0.58, 95% CI 0.37–0.91). Majority of AGYW were not aware of any kind of PrEP. Those with higher risk behavior, i.e. alcohol dependents or multiple sexual partners, were more aware of oral PrEP. Interventions to increase awareness among female youth are needed. Improving PrEP awareness is critical to increasing PrEP uptake among high-risk AGYW in Uganda.
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影响因子：
4.4
作者：
Koechlin FM;Fonner VA;Dalglish SL;O'Reilly KR;Baggaley R;Grant RM;Rodolph M;Hodges-Mameletzis I;Kennedy CE
通讯作者：
Kennedy CE
DOI：
10.1093/infdis/jiu493
发表时间：
2014-12-01
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Elmes J;Nhongo K;Ward H;Hallett T;Nyamukapa C;White PJ;Gregson S
通讯作者：
Gregson S
影响因子：
3.7
作者：
Maseko, Bertha;Hill, Lauren M.;Rosenberg, Nora E.
通讯作者：
Rosenberg, Nora E.
影响因子：
4.5
作者：
Govender, Desiree;Naidoo, Saloshni;Taylor, Myra
通讯作者：
Taylor, Myra
影响因子：
16.1
作者：
Koss, Catherine A.;Charlebois, Edwin D.;Havlir, Diane V.
通讯作者：
Havlir, Diane V.