Preference for daily versus on-demand pre-exposure prophylaxis for HIV and correlates among men who have sex with men: the China Real-world Oral PrEP Demonstration study.
Preference for daily versus on-demand pre-exposure prophylaxis for HIV and correlates among men who have sex with men: the China Real-world Oral PrEP Demonstration study.
复制标题
男男性行为者对每日艾滋病毒暴露前预防与按需艾滋病毒暴露前预防的偏好及其相关性：中国真实世界口服 PrEP 示范研究
DOI：
10.1002/jia2.25667
复制
发表时间：
2021-03
影响因子：
6
通讯作者：
CROPrEP Group
中科院分区：
文献类型：
--
作者：
Zhang J;Xu JJ;Wang HY;Huang XJ;Chen YK;Wang H;Chu ZX;Hu QH;He XQ;Li Y;Zhang LK;Hu ZL;Bao RT;Li SC;Li H;Ding HB;Jiang YJ;Geng WQ;Sylvia S;Shang H;CROPrEP Group
This study explores the preference for daily versus on‐demand pre‐exposure prophylaxis (PrEP) among men who have sex with men (MSM) in developing countries when both regimens are available. From 11 December 2018 to 19 October 2019, we recruited MSM for an open‐label real‐world PrEP demonstration study in four major cities in China. Subjects selected their preferred PrEP (oral tenofovir/emtricitabine) regimen (daily vs. on‐demand) at recruitment and underwent on‐site screening before initiation of PrEP. We used logistic regression to assess preference for daily PrEP and correlates. Of 1933 recruited MSM, the median age was 29 years, 7.6% was currently married to or living with a female; the median number of male sexual partners was four and 6.1% had used post‐exposure prophylaxis (PEP) in the previous six months. HIV infection risk was subjectively determined as very high (>75%) in 7.0% of subjects, high (50% to 75%) in 13.3%, moderate (25% to 49%) in 31.5% and low or none (0% to 24%) in 48.1%. On average, participants preferred on‐demand PrEP over daily PrEP (1104 (57.1%) versus 829 (42.9%)) at recruitment. In multivariable analysis, currently being married to or living with a female was associated with 14.6 percentage points lower preference for daily PrEP (marginal effect = −0.146 [95% CI: −0.230, −0.062], p = 0.001); whereas the number of male sexual partners (marginal effect = 0.003 [95% CI: 0.000, 0.005], p = 0.034) and a subjective assessment of being very high risk of HIV infection (vs. low and no risk, marginal effect size = 0.105 [95% CI: 0.012, 0.198], p = 0.027) were associated with increased preference for daily versus on‐demand PrEP. Among the 1933 potential participants, 721 (37.3%) did not attend the subsequent on‐site screening. Lower‐income, lower education level, lower subjective expected risk of HIV infection risk and younger age positively correlated with the absence of on‐site screening. MSM in China prefer both daily and on‐demand PrEP when both regimens are provided free. Social structural factors and subjective risk of HIV infection have significant impacts on PrEP preference and use. The upcoming national PrEP guideline should consider incorporating both regimens and the correlates to help implement PrEP in China.
登录
查看更多内容
DOI：
10.1097/qai.0000000000001251
发表时间：
2017-03-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Parsons JT;Rendina HJ;Lassiter JM;Whitfield TH;Starks TJ;Grov C
通讯作者：
Grov C
影响因子：
168.9
作者：
Beyrer, Chris;Baral, Stefan D.;van Griensven, Frits;Goodreau, Steven M.;Chariyalertsak, Suwat;Wirtz, Andrea L.;Brookmeyer, Ron
通讯作者：
Brookmeyer, Ron
影响因子：
6
作者：
Hoornenborg E;Achterbergh RC;van der Loeff MFS;Davidovich U;van der Helm JJ;Hogewoning A;van Duijnhoven YT;Sonder GJ;de Vries HJ;Prins M;Amsterdam PrEP Project team in the HIV Transmission Elimination AMsterdam Initiative
通讯作者：
Amsterdam PrEP Project team in the HIV Transmission Elimination AMsterdam Initiative
影响因子：
3.7
作者：
Robineau O;Velter A;Barin F;Boelle PY
通讯作者：
Boelle PY
影响因子：
16.1
作者：
Molina, Jean-Michel;Charreau, Isabelle;Meyer, Laurence
通讯作者：
Meyer, Laurence