Healing of intrabony defects following regenerative surgery by means of single-flap approach in conjunction with either hyaluronic acid or an enamel matrix derivative: a 24-month randomized controlled clinical trial.
Healing of intrabony defects following regenerative surgery by means of single-flap approach in conjunction with either hyaluronic acid or an enamel matrix derivative: a 24-month randomized controlled clinical trial.
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DOI：
10.1007/s00784-021-03822-x
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发表时间：
2021-08
影响因子：
3.4
通讯作者：
Iacono R
中科院分区：
文献类型：
--
作者：
Pilloni A;Rojas MA;Marini L;Russo P;Shirakata Y;Sculean A;Iacono R
本随机对照临床试验的目的是比较再生牙周手术后骨内缺损的临床结果，使用单瓣法（SFA）结合透明质酸（HA）或釉基质衍生物（EMD）。32例健康受试者的32个骨内缺损被随机分配：HA（试验组）或EMD（对照组）。在基线、术后12、18和24个月记录临床附着水平（CAL）、探诊深度（PD）、牙龈退缩（REC）和探诊出血（BOP）。在24个月时，两种治疗均导致具有统计学意义的临床改善，表现为PD降低和CAL增加（p<0.001）。试验部位的平均CAL增益为2.19±1.11 mm，对照部位为2.94±1.12 mm（p=0.067）。对照组的PD减少（4.5±0.97 mm）在统计学上显著高于试验组（3.31±0.70 mm）（p=0.001）。分别在87.5%和62.5%的试验和对照部位观察到CAL增益≤ 3 mm。试验部位的REC值略低于对照部位。治疗组间BOP无统计学显著差异。目前的研究结果表明，与基线相比，两种治疗均导致统计学显著的临床改善，尽管与使用HA相比，EMD的应用导致统计学显著更高的PD减少。HA与SFA联合使用导致显著的PD减少和CAL增加，指出这种材料在再生牙周手术中的潜在临床相关性。
The aim of this randomized controlled clinical trial was to compare the clinical outcomes obtained in intrabony defects following regenerative periodontal surgery using the single-flap approach (SFA) in conjunction with either hyaluronic acid (HA) or enamel matrix derivative (EMD). Thirty-two intrabony defects in 32 healthy subjects were randomly assigned: HA (test group) or EMD (control group). Clinical attachment level (CAL), probing depth (PD), gingival recession (REC), and bleeding on probing (BOP) were recorded at baseline,12, 18, and 24 months after surgery. At 24 months, both treatments resulted in statistically significant clinical improvements evidenced by PD-reduction and CAL-gain (p<0.001). The mean CAL-gain was 2.19±1.11 mm in the test and 2.94±1.12 mm in the control sites (p=0.067). PD-reduction was statistically significantly higher for the control group (4.5±0.97 mm) than the test group (3.31±0.70 mm), (p=0.001). CAL-gain ≤ 3 mm was observed in 87.5% and in 62.5% of the test and control sites, respectively. Test sites showed slightly lower REC values than the control sites. No statistically significant differences were found for BOP between treatments. The present findings indicate that both treatments led to statistically significant clinical improvements compared to baseline, although the application of EMD resulted in statistically significantly higher PD-reduction compared to the use of HA. The use of HA in conjunction with a SFA resulted in significant PD-reduction and CAL-gain, pointing to the potential clinical relevance of this material in regenerative periodontal surgery.
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影响因子：
3.4
作者：
Asparuhova MB;Chappuis V;Stähli A;Buser D;Sculean A
通讯作者：
Sculean A
DOI：
10.4103/1947-2714.112473
发表时间：
2013-05
期刊：
North American journal of medical sciences
影响因子：
--
作者：
Dahiya P;Kamal R
通讯作者：
Kamal R
影响因子：
1.9
作者：
Lanzrein, Carla;Guldener, Kevin;Sculean, Anton
通讯作者：
Sculean, Anton
影响因子：
18.6
作者：
Lang, NP
通讯作者：
Lang, NP
影响因子：
4.3
作者：
Johannsen, Annsofi;Tellefsen, Monica;Johannsen, Gunnar
通讯作者：
Johannsen, Gunnar