Chemical diversity, medicinal potentialities, biosynthesis, and pharmacokinetics of anthraquinones and their congeners derived from marine fungi: a comprehensive update.
Chemical diversity, medicinal potentialities, biosynthesis, and pharmacokinetics of anthraquinones and their congeners derived from marine fungi: a comprehensive update.
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海洋真菌作为结构独特的次级代谢产物的多产生产者受到过度关注，提供了作为当前治疗剂的替代物或缀合物的有希望的潜力，而现有的研究仅在次级代谢产物多样性和潜在的工业应用方面触及了表面，因为迄今为止只有一小部分生物活性天然产物已从海洋来源的真菌中鉴定出来。来源于丝状真菌的蒽醌是一大类独特的含有聚酮化合物的化合物，其特征在于共同的9，10-二氧代蒽核，而它们的衍生物通过酶促反应如甲基化、氧化或二聚化产生，以产生多种蒽醌衍生物。大量报道的蒽醌类化合物及其衍生物具有显著的生物活性，并具有抗癌、抗菌、抗氧化和抗炎等生物活性，具有很高的经济、商业和生物医学潜力。因此，在这种情况下，本审查全面涵盖了国家的最先进的超过20年的约208个结构不同的蒽醌及其衍生物分离自不同物种的海洋来源的真菌属沿着与他们的生物活性的报告，只要适用。此外，在这份手稿中，我们将简要介绍最近的见解集中在他们的实验证明的生物合成路线。此外，对所有报道的化合物的计算机模拟药物相似性和药代动力学特性进行了广泛研究，这有趣地突出了20种含蒽醌化合物的列表，这些化合物可被视为潜在的药物先导支架。海洋真菌作为结构独特的次级代谢产物的多产者受到过度关注。虽然它们是目前治疗药物的有前途的替代品或缀合物，但迄今为止的研究仅涉及其次级代谢产物的多样性。
Marine fungi receive excessive attention as prolific producers of structurally unique secondary metabolites, offering promising potential as substitutes or conjugates for current therapeutics, whereas existing research has only scratched the surface in terms of secondary metabolite diversity and potential industrial applications as only a small share of bioactive natural products have been identified from marine-derived fungi thus far. Anthraquinones derived from filamentous fungi are a distinct large group of polyketides containing compounds which feature a common 9,10-dioxoanthracene core, while their derivatives are generated through enzymatic reactions such as methylation, oxidation, or dimerization to produce a large variety of anthraquinone derivatives. A considerable number of reported anthraquinones and their derivatives have shown significant biological activities as well as highly economical, commercial, and biomedical potentialities such as anticancer, antimicrobial, antioxidant, and anti-inflammatory activities. Accordingly, and in this context, this review comprehensively covers the state-of-art over 20 years of about 208 structurally diverse anthraquinones and their derivatives isolated from different species of marine-derived fungal genera along with their reported bioactivity wherever applicable. Also, in this manuscript, we will present in brief recent insights centred on their experimentally proved biosynthetic routes. Moreover, all reported compounds were extensively investigated for their in-silico drug-likeness and pharmacokinetics properties which intriguingly highlighted a list of 20 anthraquinone-containing compounds that could be considered as potential drug lead scaffolds. Marine-derived fungi receive excessive attention as prolific producers of structurally unique secondary metabolites. Whilst they are promising substitutes or conjugates for current therapeutics, so far research has only touched on their secondary metabolite diversity.
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影响因子：
5.1
作者：
Brauers, G;Edrada, RA;Schaumann, K
通讯作者：
Schaumann, K
影响因子：
16
作者：
Atanasov AG;Waltenberger B;Pferschy-Wenzig EM;Linder T;Wawrosch C;Uhrin P;Temml V;Wang L;Schwaiger S;Heiss EH;Rollinger JM;Schuster D;Breuss JM;Bochkov V;Mihovilovic MD;Kopp B;Bauer R;Dirsch VM;Stuppner H
通讯作者：
Stuppner H
影响因子：
1.1
作者：
BIRCH, AJ;DONOVAN, FW
通讯作者：
DONOVAN, FW
影响因子：
2.2
作者：
Ee, G. C. L.;Wen, Y. P.;Lee, H. L.
通讯作者：
Lee, H. L.
影响因子：
5
作者：
Chiang, Yi-Ming;Oakley, Berl R.;Keller, Nancy P.;Wang, Clay C. C.
通讯作者：
Wang, Clay C. C.