Juvenile idiopathic arthritis polygenic risk scores are associated with cardiovascular phenotypes in early adulthood: a phenome-wide association study.
Juvenile idiopathic arthritis polygenic risk scores are associated with cardiovascular phenotypes in early adulthood: a phenome-wide association study.
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DOI：
10.1186/s12969-022-00760-0
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发表时间：
2022-11-19
影响因子：
2.5
通讯作者：
Relton, Caroline L.
中科院分区：
文献类型：
--
作者：
Clarke, Sarah L. N.;Jones, Hannah J.;Sharp, Gemma C.;Easey, Kayleigh E.;Hughes, Alun D.;Ramanan, Athimalaipet, V;Relton, Caroline L.
人们越来越担心青少年特发性关节炎（JIA）患者的长期心血管健康。在这项研究中，我们评估了JIA多基因风险与生命早期心血管表型（心血管危险因素，早期动脉粥样硬化/动脉硬化标志物，心脏结构和功能测量）之间的关联。使用最近JIA全基因组关联研究的单核苷酸多态性（SNP）权重，为来自Avon父母和儿童纵向研究的2，815名参与者构建JIA多基因风险评分（PRS）。使用线性和逻辑回归评估JIA PRS和24岁时心血管表型之间的关联。对于具有强有力证据的结果，进行了进一步分析，以检查这些关联在生命早期（从7岁起）的表现。JIA PRS与舒张压相关（β 0.062，95% CI 0.026至0.099，P = 0.001），胰岛素（β 0.050，95% CI 0.011 ~ 0.090，P = 0.013），胰岛素抵抗指数（HOMA2_IR，β 0.054，95% CI 0.014 - 0.095，P = 0.009），log hsCRP（β 0.053，95% CI 0.011至0.095，P = 0.014），腰围（β 0.041，95% CI 0.007至0.075，P = 0.017）、脂肪质量指数（β 0.049，95% CI 0.016至0.083，P = 0.004）和体重指数（β 0.046，95% CI 0.011至0.081，P = 0.010）。对于人体测量和舒张压，有证据表明，从7岁开始与JIA PRS相关。多项敏感性分析的结果一致。JIA的遗传易感性与多种心血管危险因素相关，支持JIA心血管风险增加的假设。我们的研究结果表明，心血管风险是JIA的核心特征，而不是继发于疾病活动/治疗，心血管风险咨询应成为患者护理的一部分。在线版本包含补充材料，可通过10.1186/s12969-022-00760-0获得。
There is growing concern about the long-term cardiovascular health of patients with juvenile idiopathic arthritis (JIA). In this study we assessed the association between JIA polygenic risk and cardiovascular phenotypes (cardiovascular risk factors, early atherosclerosis/arteriosclerosis markers, and cardiac structure and function measures) early in life. JIA polygenic risk scores (PRSs) were constructed for 2,815 participants from the Avon Longitudinal Study of Parents and Children, using the single nucleotide polymorphism (SNP) weights from the most recent JIA genome wide association study. The association between JIA PRSs and cardiovascular phenotypes at age 24 years was assessed using linear and logistic regression. For outcomes with strong evidence of association, further analysis was undertaken to examine how early in life (from age seven onwards) these associations manifest. The JIA PRS was associated with diastolic blood pressure (β 0.062, 95% CI 0.026 to 0.099, P = 0.001), insulin (β 0.050, 95% CI 0.011 to 0.090, P = 0.013), insulin resistance index (HOMA2_IR, β 0.054, 95% CI 0.014 to 0.095, P = 0.009), log hsCRP (β 0.053, 95% CI 0.011 to 0.095, P = 0.014), waist circumference (β 0.041, 95% CI 0.007 to 0.075, P = 0.017), fat mass index (β 0.049, 95% CI 0.016 to 0.083, P = 0.004) and body mass index (β 0.046, 95% CI 0.011 to 0.081, P = 0.010). For anthropometric measures and diastolic blood pressure, there was suggestive evidence of association with JIA PRS from age seven years. The findings were consistent across multiple sensitivity analyses. Genetic liability to JIA is associated with multiple cardiovascular risk factors, supporting the hypothesis of increased cardiovascular risk in JIA. Our findings suggest that cardiovascular risk is a core feature of JIA, rather than secondary to the disease activity/treatment, and that cardiovascular risk counselling should form part of patient care. The online version contains supplementary material available at 10.1186/s12969-022-00760-0.
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影响因子：
7.2
作者：
KANNEL, WB;CUPPLES, LA;HIGGINS, M
通讯作者：
HIGGINS, M
影响因子：
9.2
作者：
Choi, Shing Wan;O'Reilly, Paul F.
通讯作者：
O'Reilly, Paul F.
影响因子：
5
作者：
Breda, L.;Di Marzio, D.;Mohn, A.
通讯作者：
Mohn, A.
DOI：
10.1136/bmj.j2099
发表时间：
2017-05-23
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Hippisley-Cox J;Coupland C;Brindle P
通讯作者：
Brindle P
影响因子：
2.5
作者：
Bos, G. J. F. Joyce;Lelieveld, Otto T. H. M.;Dijkstra, Pieter U.
通讯作者：
Dijkstra, Pieter U.