Activation of Early Silent Synapses by Spontaneous Synchronous Network Activity Limits the Range of Neocortical Connections
Activation of Early Silent Synapses by Spontaneous Synchronous Network Activity Limits the Range of Neocortical Connections
复制标题
自发同步网络活动激活早期沉默突触限制了新皮质连接的范围
DOI：
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发表时间：
2005
影响因子：
5.3
通讯作者：
A. D. de Lima
中科院分区：
文献类型：
--
作者：
T. Voigt;T. Opitz;A. D. de Lima
During the early development of neocortical networks, many glutamatergic synapses lack AMPA receptors and are physiologically silent. We show in neocortical cultures that spontaneous synchronous network activity is able to convert silent synapses to active synapses by the incorporation of AMPA receptors into synaptic complexes throughout the network within a few minutes. To test the effect of synaptic activation on the connectivity of neuronal populations, we created separated neuronal networks that could innervate each other. We allowed outgrowing axons to invade the neighboring network either before or after the onset of synchronous network activity. In the first case, both subnetworks connected to each other and synchronized their activity, whereas in the second case, axonal connections failed to form and network activity did not synchronize between compartments. We conclude that early spontaneous synchronous network activity triggers a global AMPAfication of immature synapses, which in turn prevents later-arriving axons from forming afferent connections. This activity-dependent process may set the range of corticocortical connections during early network development before experience-dependent mechanisms begin elaborating the mature layout of the neocortical connections and modules.
影响因子：
56.9
作者：
Shi, SH;Hayashi, Y;Malinow, R
通讯作者：
Malinow, R
体外猫感觉运动皮层神经元的缓慢电导及其在缓慢兴奋性变化中的作用。
影响因子：
2.5
作者：
Schwindt,PC;Spain,WJ;Foehring,RC;Chubb,MC;Crill,WE
通讯作者：
Crill,WE