Short Communication: Phenotypic Changes in Peripheral Blood Monocytes of Cynomolgus Monkeys Acutely Infected with Simian Immunodeficiency Virus
Short Communication: Phenotypic Changes in Peripheral Blood Monocytes of Cynomolgus Monkeys Acutely Infected with Simian Immunodeficiency Virus
复制标题
短通讯：猿猴免疫缺陷病毒急性感染食蟹猴外周血单核细胞表型变化
DOI：
10.1089/aid.1998.14.1181
复制
发表时间：
1998
影响因子：
1.5
通讯作者：
Y. Yosikawa
中科院分区：
文献类型：
--
作者：
I. Otani;H. Akari;K. Nam;K. Mori;E. Suzuki;H. Shibata;K. Doi;K. Terao;Y. Yosikawa
ABSTRACT The quantitative and phenotypic changes of peripheral blood monocytes during the acute stage of simian immunodeficiency virus infection were investigated. We inoculated intravenously three cynomolgus monkeys (Macaca fascicularis) with 100 TCID50 of SIVmac239 and collected whole blood twice a week until 35 days postinoculation. We found that the relative number of monocytes in peripheral blood leukocytes significantly increased at 7–17 days postinoculation. This increase was concomitant with the peak of primary SIV antigenemia. To determine if the monocytes observed during the acute stage were phenotypically altered, they were periodically examined for the expression of surface markers (i.e., CD11b, CD14, CD16, CD29, D32, CD56, CD62L, CD64, CD80, and MHC-II-DR) by flow cytometry. The results showed that the expression levels of CD14 and CD56 on most of the monocytes were remarkably reduced at 7–17 days postinoculation, and a new subpopulation, CD14lowCD16+CD80+ monocytes, was clearly detected at 1...
登录
查看更多内容
影响因子：
20.3
作者：
SALEH, MN;GOLDMAN, SJ;MUNN, DH
通讯作者：
MUNN, DH
影响因子：
56.9
作者：
ZHU, TF;MO, HM;HO, DD
通讯作者：
HO, DD
骨髓单核细胞/巨噬细胞是恒河猴中致病性和非致病性猿猴免疫缺陷病毒（SIVmac）分离株的早期细胞靶标。
DOI：
--
发表时间：
1995
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Mandell,CP;Jain,NC;Miller,CJ;Dandekar,S
通讯作者：
Dandekar,S
恒河猴共刺激分子CD80（B7-1）和CD86（B7-2）的分子克隆及比较分析。
影响因子：
4.3
作者：
Zhang,D;Johnson,RP
通讯作者：
Johnson,RP