Bloch-Siegert B1+-mapping for human cardiac (31) P-MRS at 7 Tesla.
Bloch-Siegert B1+-mapping for human cardiac (31) P-MRS at 7 Tesla.
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DOI：
10.1002/mrm.26005
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发表时间：
2016-10
影响因子：
3.3
通讯作者：
Rodgers, Christopher T.
中科院分区：
文献类型：
--
作者：
Clarke, William T.;Robson, Matthew D.;Rodgers, Christopher T.
磷磁共振波谱(31P-MRS)是研究活体组织能量学的有力工具。心脏31P-MRS通常是使用表面线圈进行的，表面线圈在整个心肌产生不均匀的激励场。为了定量分析31P-MR谱，需要精确测量(因此是翻转角)。为此，我们演示了Bloch-Siegert映射方法。当存在多个谱峰时，我们比较了Bloch-Siegert映射的捕获策略。我们优化了7T的Bloch-Siegert敏化(费米)脉冲用于心脏31P-MRS，并将其应用于三维(3D)化学位移成像序列。我们在幻影和骨骼肌中验证了这一点(与双TR方法相反)，并在7T时提供了第一个心脏31P-MAP。Bloch-Siegert方法具有很强的相关性(Pearson‘s r=0.90和0.84)，并且与模体中的多tr方法和肌肉中的双tr方法相比有25赫兹的偏差。对5名正常志愿者的心脏三维地形图进行了测量。基于磷酸肌酸和α-三磷酸腺苷的MAP具有很强的相关性(r=0.62)，证实了该方法是T1不敏感的。3D 31P Bloch-Siegert标测图与幻影和骨骼肌中的参考方法一致。这是第一种适用于7T人体心脏31P标测的方法。Magn Reson Med 76：1047-1058,2016。©2015作者。《医学中的磁共振》由威利期刊公司代表国际医学磁共振学会出版。这是一篇在知识共享署名许可证条款下开放获取的文章，该许可证允许在任何媒体上使用、分发和复制，只要正确引用原始作品即可。
Phosphorus MR spectroscopy (31P‐MRS) is a powerful tool for investigating tissue energetics in vivo. Cardiac 31P‐MRS is typically performed using surface coils that create an inhomogeneous excitation field across the myocardium. Accurate measurements of (and hence flip angle) are necessary for quantitative analysis of 31P‐MR spectra. We demonstrate a Bloch‐Siegert ‐mapping method for this purpose. We compare acquisition strategies for Bloch‐Siegert ‐mapping when there are several spectral peaks. We optimize a Bloch‐Siegert sensitizing (Fermi) pulse for cardiac 31P‐MRS at 7 Tesla (T) and apply it in a three‐dimensional (3D) chemical shift imaging sequence. We validate this in phantoms and skeletal muscle (against a dual‐TR method) and present the first cardiac 31P ‐maps at 7T. The Bloch‐Siegert method correlates strongly (Pearson's r = 0.90 and 0.84) and has bias <25 Hz compared with a multi‐TR method in phantoms and dual‐TR method in muscle. Cardiac 3D ‐maps were measured in five normal volunteers. maps based on phosphocreatine and alpha‐adenosine‐triphosphate correlated strongly (r = 0.62), confirming that the method is T1 insensitive. The 3D 31P Bloch‐Siegert ‐mapping is consistent with reference methods in phantoms and skeletal muscle. It is the first method appropriate for 31P ‐mapping in the human heart at 7T. Magn Reson Med 76:1047–1058, 2016. © 2015 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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