The SCFA Receptor GPR43 and Energy Metabolism.
The SCFA Receptor GPR43 and Energy Metabolism.
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DOI：
10.3389/fendo.2014.00085
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发表时间：
2014
影响因子：
5.2
通讯作者：
Tsujimoto G
中科院分区：
文献类型：
--
作者：
Kimura I;Inoue D;Hirano K;Tsujimoto G
游离脂肪酸(FFA)是人体必需的营养物质，通过与FFA受体结合，在多种细胞过程中发挥信号分子的作用。在这些受体中，GPR43被短链脂肪酸(如醋酸、丙酸和丁酸)激活。在摄食过程中，肠道中的膳食纤维通过微生物发酵产生单链脂肪酸，这些单链脂肪酸成为宿主的重要能量来源。肠道微生物区系影响宿主的营养获取和能量调节，并可能影响肥胖、胰岛素抵抗和糖尿病的发展。最近，GPR43被报道调节胃肠道和脂肪组织中的宿主能量动态平衡。因此，GPR43也被认为是治疗肥胖症和糖尿病等代谢紊乱的潜在药物靶点。本文对GPR43的鉴定、结构和活性进行了综述，重点介绍了GPR43在宿主能量调节中的作用，并对GPR43在肠道微生物区系介导的宿主能量调节中的生理作用进行了综述。我们还讨论了GPR43作为治疗靶点的潜力。
Free fatty acids (FFAs) are essential nutrients and act as signaling molecules in various cellular processes via binding with FFA receptors. Of these receptors, GPR43 is activated by short-chain fatty acids (SCFAs; e.g., acetate, propionate, and butyrate). During feeding, SCFAs are produced by microbial fermentation of dietary fiber in the gut, and these SCFAs become important energy sources for the host. The gut microbiota affects nutrient acquisition and energy regulation of the host and can influence the development of obesity, insulin resistance, and diabetes. Recently, GPR43 has been reported to regulate host energy homeostasis in the gastrointestinal tract and adipose tissues. Hence, GPR43 is also thought to be a potential drug target for metabolic disorders, such as obesity and diabetes. In this review, we summarize the identification, structure, and activities of GPR43, with a focus on host energy regulation, and present an essential overview of our current understanding of its physiological roles in host energy regulation that is mediated by gut microbiota. We also discuss the potential for GPR43 as a therapeutic target.
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影响因子：
7
作者：
Sanz, Yolanda;Santacruz, Arlette;Gauffin, Paola
通讯作者：
Gauffin, Paola
肠道菌群通过短链脂肪酸受体GPR43抑制胰岛素介导的脂肪积累。
影响因子：
16.6
作者：
通讯作者：
--
DOI：
10.1016/s0006-291x(03)00488-1
发表时间：
2003-04-18
影响因子：
3.1
作者：
Nilsson, NE;Kotarsky, K;Olde, B
通讯作者：
Olde, B
DOI：
10.1152/ajpendo.00229.2010
发表时间：
2011-01-01
影响因子：
5.1
作者：
Bjursell, Mikael;Admyre, Therese;Bohlooly-Y, Mohammad
通讯作者：
Bohlooly-Y, Mohammad
影响因子：
4.8
作者：
Brown, AJ;Goldsworthy, SM;Dowell, SJ
通讯作者：
Dowell, SJ