Direct effects of transcranial electric stimulation on brain circuits in rats and humans.
Direct effects of transcranial electric stimulation on brain circuits in rats and humans.
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DOI：
10.1038/s41467-018-02928-3
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发表时间：
2018-02-02
影响因子：
16.6
通讯作者：
Berényi A
中科院分区：
文献类型：
--
作者：
Vöröslakos M;Takeuchi Y;Brinyiczki K;Zombori T;Oliva A;Fernández-Ruiz A;Kozák G;Kincses ZT;Iványi B;Buzsáki G;Berényi A
Transcranial electric stimulation is a non-invasive tool that can influence brain activity; however, the parameters necessary to affect local circuits in vivo remain to be explored. Here, we report that in rodents and human cadaver brains, ~75% of scalp-applied currents are attenuated by soft tissue and skull. Using intracellular and extracellular recordings in rats, we find that at least 1 mV/mm voltage gradient is necessary to affect neuronal spiking and subthreshold currents. We designed an ‘intersectional short pulse’ stimulation method to inject sufficiently high current intensities into the brain, while keeping the charge density and sensation on the scalp surface relatively low. We verify the regional specificity of this novel method in rodents; in humans, we demonstrate how it affects the amplitude of simultaneously recorded EEG alpha waves. Our combined results establish that neuronal circuits are instantaneously affected by intensity currents that are higher than those used in conventional protocols. Though transcranial electric stimulation has been used to influence brain activity, it is debated whether neuronal spiking activity is directly affected by commonly-used protocols. Here, the authors quantify the voltage gradients necessary to instantaneously affect neuronal spiking and show that they are higher than commonly-used protocols.
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影响因子：
3.5
作者：
Latikka, J;Kuurne, T;Eskola, H
通讯作者：
Eskola, H
影响因子：
3.5
作者：
Dmochowski, Jacek P.;Bikson, Marom;Parra, Lucas C.
通讯作者：
Parra, Lucas C.
影响因子：
7.7
作者：
Brunoni, Andre Russowsky;Nitsche, Michael A.;Bolognini, Nadia;Bikson, Marom;Wagner, Tim;Merabet, Lotfi;Edwards, Dylan J.;Valero-Cabre, Antoni;Rotenberg, Alexander;Pascual-Leone, Alvaro;Ferrucci, Roberta;Priori, Alberto;Boggio, Paulo Sergio;Fregni, Felipe
通讯作者：
Fregni, Felipe
影响因子：
16.6
作者：
Lafon B;Henin S;Huang Y;Friedman D;Melloni L;Thesen T;Doyle W;Buzsáki G;Devinsky O;Parra LC;A Liu A
通讯作者：
A Liu A
影响因子：
2.9
作者：
Antal A;Paulus W
通讯作者：
Paulus W