Transcranial alternating current stimulation (tACS).

Transcranial alternating current stimulation (tACS).
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DOI:
10.3389/fnhum.2013.00317
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发表时间:
2013
影响因子:
2.9
通讯作者:
Paulus W
Paulus W
中科院分区:
医学3区
文献类型:
--
作者:
Antal A;Paulus W

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经颅交流电刺激(tACS)似乎有可能通过直接干扰大脑皮层节律,开启人类大脑无创电刺激领域的新时代。期望同步(通过一个单一的谐振频率)或去同步(例如,通过应用几个频率)皮层振荡。如果使用时间足够长,可能会导致神经可塑性效应。在θ范围内,当在相位中应用时,它可以改善认知。α节律可以改善运动性能,而β节律干扰可能会使它们恶化。具有α和β频率的TACS具有诱导视网膜光幻视的高可能性。伽马射线侵入可能会干扰注意力。在“涟漪”范围内的刺激诱导运动皮层(M1)中的强度依赖性抑制或兴奋,最可能是通过神经元网络的夹带,而在低kHz范围内的刺激通过神经元膜干扰诱导兴奋。200 kHz范围内的TACS可能在肿瘤学中具有潜力。
Transcranial alternating current stimulation (tACS) seems likely to open a new era of the field of noninvasive electrical stimulation of the human brain by directly interfering with cortical rhythms. It is expected to synchronize (by one single resonance frequency) or desynchronize (e.g., by the application of several frequencies) cortical oscillations. If applied long enough it may cause neuroplastic effects. In the theta range it may improve cognition when applied in phase. Alpha rhythms could improve motor performance, whereas beta intrusion may deteriorate them. TACS with both alpha and beta frequencies has a high likelihood to induce retinal phosphenes. Gamma intrusion can possibly interfere with attention. Stimulation in the “ripple” range induces intensity dependent inhibition or excitation in the motor cortex (M1) most likely by entrainment of neuronal networks, whereas stimulation in the low kHz range induces excitation by neuronal membrane interference. TACS in the 200 kHz range may have a potential in oncology.
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