Understanding the Exchange of Systemic HDL Particles Into the Brain and Vascular Cells Has Diagnostic and Therapeutic Implications for Neurodegenerative Diseases.
Understanding the Exchange of Systemic HDL Particles Into the Brain and Vascular Cells Has Diagnostic and Therapeutic Implications for Neurodegenerative Diseases.
复制标题
DOI：
10.3389/fphys.2021.700847
复制
发表时间：
2021
影响因子：
4
通讯作者：
Yassine HN
中科院分区：
文献类型：
--
作者：
Van Valkenburgh J;Meuret C;Martinez AE;Kodancha V;Solomon V;Chen K;Yassine HN
高密度脂蛋白 (HDL) 是复杂的异质脂蛋白颗粒，由载脂蛋白大家族组成，形成具有不同形状、大小和功能的亚种，并在大脑和外周中合成。 HDL 载脂蛋白是阿尔茨海默病 (AD) 病理学和血管性痴呆的重要决定因素，对大脑淀粉样蛋白 -β (Aβ) 积累和血管功能具有中枢和外周影响，然而，HDL 颗粒 (HLD-P) 在中枢神经系统 (CNS) 和体循环之间交换其蛋白质和脂质成分的程度仍不清楚。在这篇综述中，我们描述了 HDL 的结构和组成如何实现大脑、脑脊液 (CSF) 室和血管细胞之间的交换，最终影响大脑淀粉样蛋白代谢和动脉粥样硬化。因此，我们随后阐明 HDL-P 的修饰如何对脑血管和神经退行性疾病具有诊断和治疗潜力。
High-density lipoproteins (HDLs) are complex, heterogenous lipoprotein particles, consisting of a large family of apolipoproteins, formed in subspecies of distinct shapes, sizes, and functions and are synthesized in both the brain and the periphery. HDL apolipoproteins are important determinants of Alzheimer’s disease (AD) pathology and vascular dementia, having both central and peripheral effects on brain amyloid-beta (Aβ) accumulation and vascular functions, however, the extent to which HDL particles (HLD-P) can exchange their protein and lipid components between the central nervous system (CNS) and the systemic circulation remains unclear. In this review, we delineate how HDL’s structure and composition enable exchange between the brain, cerebrospinal fluid (CSF) compartment, and vascular cells that ultimately affect brain amyloid metabolism and atherosclerosis. Accordingly, we then elucidate how modifications of HDL-P have diagnostic and therapeutic potential for brain vascular and neurodegenerative diseases.
登录
查看更多内容
影响因子：
4.7
作者：
Carney, Christiane E.;Lenov, Ivan L.;Baker, Catherine J.;MacRenaris, Keith W.;Eckermann, Amanda L.;Sligar, Stephen G.;Meade, Thomas J.
通讯作者：
Meade, Thomas J.
DOI：
10.1021/jp8108286
发表时间：
2009-05-07
期刊：
The journal of physical chemistry. B
影响因子：
--
作者：
Briley-Saebo KC;Geninatti-Crich S;Cormode DP;Barazza A;Mulder WJ;Chen W;Giovenzana GB;Fisher EA;Aime S;Fayad ZA
通讯作者：
Fayad ZA
影响因子：
4.7
作者：
Balazs, Z;Panzenboeck, U;Sattler, W
通讯作者：
Sattler, W
影响因子：
9.3
作者：
Cudaback E;Li X;Yang Y;Yoo T;Montine KS;Craft S;Montine TJ;Keene CD
通讯作者：
Keene CD
影响因子：
82.9
作者：
Blanchard JW;Bula M;Davila-Velderrain J;Akay LA;Zhu L;Frank A;Victor MB;Bonner JM;Mathys H;Lin YT;Ko T;Bennett DA;Cam HP;Kellis M;Tsai LH
通讯作者：
Tsai LH