Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetes.
Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetes.
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DOI：
10.1016/j.bone.2011.06.016
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发表时间：
2012-02
期刊：
影响因子：
4.1
通讯作者：
Lecka-Czernik, B.
中科院分区：
文献类型：
--
作者：
Krings, A.;Rahman, S.;Huang, S.;Lu, Y.;Czernik, P. J.;Lecka-Czernik, B.
脂肪占据骨腔的重要部分，但其功能在很大程度上是未知的。骨髓脂肪在衰老过程中和影响能量代谢的条件下膨胀，表明骨骼中的脂肪与其他脂肪库处于类似的调节机制下。另一方面，它的位置可能决定在维持骨重建和造血环境中的特定功能。我们已经证明，骨髓脂肪具有独特的表型，它类似于白色和棕色脂肪组织（分别为WAT和BAT）。骨髓脂肪细胞表达棕色脂肪细胞的基因标记，其水平为BAT的特征，包括转录因子Prdm 16和产热调节因子，如脱碘酶2（Dio 2）和PGC 1 α。BAT特异性基因标记物的表达水平在24月龄的C57 BL/6和糖尿病黄色琼脂糖Avy/a小鼠的骨中降低，这暗示了随着衰老和糖尿病发生的骨髓脂肪的功能变化。给药降糖TZD罗格列酮（可使细胞对胰岛素敏感并增加脂肪细胞代谢功能）可显著增加血糖正常的C57 BL/6小鼠骨髓中BAT（UCP 1、PGC 1 α、Dio 2、β3AR、Prdm 16和FoxC 2）和WAT（脂联素和瘦素）基因表达，但未能增加糖尿病小鼠中BAT（但不是WAT）基因标记物的表达。总之，骨髓脂肪的代谢表型结合了BAT和WAT特征。随着年龄的增长和糖尿病，BAT样特征的减少可能有助于支持骨重建和造血的骨髓环境的负面变化。
Fat occupies a significant portion of bone cavity however its function is largely unknown. Marrow fat expands during aging and in conditions which affect energy metabolism, indicating that fat in bone is under similar regulatory mechanisms as other fat depots. On the other hand, its location may determine specific functions in the maintenance of the environment for bone remodeling and hematopoiesis. We have demonstrated that marrow fat has a distinctive phenotype, which resembles both, white and brown adipose tissue (WAT and BAT, respectively). Marrow adipocytes express gene markers of brown adipocytes at levels characteristic for the BAT, including transcription factor Prdm16, and regulators of thermogenesis such as deiodinase 2 (Dio2) and PGC1α. The levels of expression of BAT-specific gene markers are decreased in bone of 24 mo old C57BL/6 and in diabetic yellow agouti Avy/a mice implicating functional changes of marrow fat occurring with aging and diabetes. Administration of antidiabetic TZD rosiglitazone, which sensitizes cells to insulin and increases adipocyte metabolic functions, significantly increased both, BAT (UCP1, PGC1α, Dio2, β3AR, Prdm16, and FoxC2) and WAT (adiponectin and leptin) gene expression in marrow of normoglycemic C57BL/6 mice, but failed to increase the expression of BAT, but not WAT, gene markers in diabetic mice. In conclusion, the metabolic phenotype of marrow fat combines both BAT and WAT characteristics. Decrease in BAT-like characteristics with aging and diabetes may contribute to the negative changes in the marrow environment supporting bone remodeling and hematopoiesis.
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影响因子：
4.3
作者：
Lecka-Czernik, Beata
通讯作者：
Lecka-Czernik, Beata
影响因子：
64.8
作者：
Enerback, S;Jacobsson, A;Kozak, LP
通讯作者：
Kozak, LP
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
6.2
作者：
Devlin, Maureen J.;Cloutier, Alison M.;Thomas, Nishina A.;Panus, David A.;Lotinun, Sutada;Pinz, Ilka;Baron, Roland;Rosen, Clifford J.;Bouxsein, Mary L.
通讯作者：
Bouxsein, Mary L.
影响因子：
5.8
作者：
Bredella, Miriam A.;Fazeli, Pouneh K.;Klibanski, Anne
通讯作者：
Klibanski, Anne