The Eyes Absent proteins in development and in developmental disorders.
The Eyes Absent proteins in development and in developmental disorders.
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DOI：
10.1042/bst20201302
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发表时间：
2021-06-30
影响因子：
3.9
通讯作者：
Hegde RS
中科院分区：
文献类型：
--
作者：
Soni UK;Roychoudhury K;Hegde RS
EYA蛋白是细胞命运决定过程和多器官发育的重要贡献者。EYA蛋白的转录调节活性以及蛋白酪氨酸磷酸酶活性可以独立地在不同情况下促进增殖、分化、形态发生和组织稳态。异常的EYA水平或活性与许多综合征和非综合征发育障碍以及癌症有关。与EYA蛋白进行的多种生物化学活性相当，它们影响一系列细胞信号传导途径。在这里，我们提供了EYA蛋白在发育中所起作用的广泛概述，并强调了已知与EYA相关器官发育和发育障碍有关的分子信号通路。
The Eyes Absent (EYA) transactivator-phosphatase proteins are important contributors to cell-fate determination processes and to the development of multiple organs. The transcriptional regulatory activity as well as the protein tyrosine phosphatase activities of the EYA proteins can independently contribute to proliferation, differentiation, morphogenesis and tissue homeostasis in different contexts. Aberrant EYA levels or activity are associated with numerous syndromic and non-syndromic developmental disorders, as well as cancers. Commensurate with the multiplicity of biochemical activities carried out by the EYA proteins, they impact upon a range of cellular signaling pathways. Here, we provide a broad overview of the roles played by EYA proteins in development, and highlight the molecular signaling pathways known to be linked with EYA-associated organ development and developmental disorders.
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影响因子：
2.7
作者：
Morillo SA;Braid LR;Verheyen EM;Rebay I
通讯作者：
Rebay I
影响因子：
3.7
作者：
Jin M;Jusiak B;Bai Z;Mardon G
通讯作者：
Mardon G
影响因子：
3.7
作者：
Jusiak B;Abulimiti A;Haelterman N;Chen R;Mardon G
通讯作者：
Mardon G
影响因子：
3.7
作者：
Davis TL;Hoi CSL;Rebay I
通讯作者：
Rebay I